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Circulating branched-chain amino acids in children with obstructive sleep apnea.
Barceló, Antonia; Bauça, Josep Miquel; Peña-Zarza, José Antonio; Morell-Garcia, Daniel; Yáñez, Aina; Pérez, Gerardo; Piérola, Javier; Toledo, Nuria; de la Peña, Mónica.
Afiliación
  • Barceló A; Servei Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Bauça JM; Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain.
  • Peña-Zarza JA; CIBER Enfermedades Respiratorias (CibeRes) (CB06/06), Spain.
  • Morell-Garcia D; Servei Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Yáñez A; Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain.
  • Pérez G; Sleep Unit, Department of Pediatrics, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Piérola J; Servei Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  • Toledo N; Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain.
  • de la Peña M; Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain.
Pediatr Pulmonol ; 52(8): 1085-1091, 2017 08.
Article en En | MEDLINE | ID: mdl-28672086
INTRODUCTION: The effects of obstructive sleep apnea (OSA) on the metabolic system are not well understood, especially in children. Recent studies have provided evidence of the modulation of insulin action by branched-chain amino acids (BCAAs) and suggested novel mechanistic relationships between glucose and amino acid metabolic pathways. We hypothesized that plasma BCAA levels may serve as biomarkers of insulin resistance and metabolic dysfunction in children with OSA. METHODS: A polysomnography was conducted for the diagnosis of OSA in 90 snoring children, in a tertiary hospital. Anthropometric and clinical data were measured and venous blood samples were collected for the measurement of plasma glucose, insulin, HbA1c, and amino acids. RESULTS: Children with OSA had significantly higher levels of BCAAs (leucine, isoleucine, and total BCAAs) compared with those without OSA (P = 0.024). A positive significant correlation was observed between insulin levels and both leucine and isoleucine (r = 0.232; P < 0.05). On multivariate regression analyses, the presence of OSA was significantly associated with leucine, isoleucine, and total BCAA concentrations (P = 0.028), whereas the arousal index was associated with leucine, valine, and total BCAA levels (P = 0.037). CONCLUSIONS: The presence of OSA and sleep fragmentation may induce changes in branched-chain amino acid metabolism in snoring children, independently of obesity. These data may suggest a new mechanism linking OSA and glucose homeostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apnea Obstructiva del Sueño / Aminoácidos de Cadena Ramificada Tipo de estudio: Diagnostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apnea Obstructiva del Sueño / Aminoácidos de Cadena Ramificada Tipo de estudio: Diagnostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos