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Photopolymerizable Zwitterionic Polymer Patterns Control Cell Adhesion and Guide Neural Growth.
Leigh, Braden L; Cheng, Elise; Xu, Linjing; Andresen, Corinne; Hansen, Marlan R; Guymon, C Allan.
Afiliación
  • Leigh BL; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
  • Cheng E; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
  • Xu L; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
  • Andresen C; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
  • Hansen MR; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
  • Guymon CA; Departments of Chemical and Biochemical Engineering, ‡Otolaryngology Head and Neck Surgery, and §Neurosurgery, University of Iowa , Iowa City, Iowa 52242, United States.
Biomacromolecules ; 18(8): 2389-2401, 2017 Aug 14.
Article en En | MEDLINE | ID: mdl-28671816
Developing materials that reduce or eliminate fibrosis encapsulation of neural prosthetic implants could significantly enhance implant fidelity by improving the tissue/electrode array interface. Here, we report on the photografting and patterning of two zwitterionic materials, sulfobetaine methacrylate (SBMA) and carboxybetaine methacrylate (CBMA), for controlling the adhesion and directionality of cells relevant to neural prosthetics. CBMA and SBMA polymers were photopolymerized and grafted on glass surfaces then characterized by X-ray photoelectron spectroscopy, water contact angle, and protein adsorption. Micropatterned surfaces were fabricated with alternating zwitterionic and uncoated bands. Fibroblasts, cells prevalent in fibrotic tissue, almost exclusively migrate and grow on uncoated bands with little to no cells present on zwitterionic bands, especially for CBMA-coated surfaces. Astrocytes and Schwann cells showed similarly low levels of cell adhesion and morphology changes when cultured on zwitterionic surfaces. Additionally, Schwann cells and inner ear spiral ganglion neuron neurites aligned well to zwitterionic patterns.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglio Espiral de la Cóclea / Metacrilatos / Neuronas Límite: Animals Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ganglio Espiral de la Cóclea / Metacrilatos / Neuronas Límite: Animals Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos