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Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain.
Kartha, Sonia; Yan, Lesan; Weisshaar, Christine L; Ita, Meagan E; Shuvaev, Vladimir V; Muzykantov, Vladimir R; Tsourkas, Andrew; Winkelstein, Beth A; Cheng, Zhiliang.
Afiliación
  • Kartha S; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Yan L; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Weisshaar CL; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Ita ME; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Shuvaev VV; Department of Systems Pharmacology and Translational Therapeutics, Center for Translational Targeted Therapeutics and Nanomedicine of the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, Center for Translational Targeted Therapeutics and Nanomedicine of the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Tsourkas A; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Winkelstein BA; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
  • Cheng Z; Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA, 19104, USA.
Adv Healthc Mater ; 6(17)2017 Sep.
Article en En | MEDLINE | ID: mdl-28671302
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Superóxido Dismutasa / Neuralgia / Antioxidantes Límite: Animals Idioma: En Revista: Adv Healthc Mater Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Superóxido Dismutasa / Neuralgia / Antioxidantes Límite: Animals Idioma: En Revista: Adv Healthc Mater Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania