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Periostin as a marker of mucosal remodelling in chronic rhinosinusitis.
Ebenezer, J A; Christensen, J M; Oliver, B G; Oliver, R A; Tjin, G; Ho, J; Habib, A R; Rimmer, J; Sacks, R; Harvey, R J.
Afiliación
  • Ebenezer JA; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
  • Christensen JM; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
  • Oliver BG; Woolcock Institute, University of Sydney, Sydney, Australia.
  • Oliver RA; Surgical and Orthopaedic Research laboratory, UNSW, Sydney, Australia.
  • Tjin G; Woolcock Institute, University of Sydney, Sydney, Australia.
  • Ho J; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
  • Habib AR; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
  • Rimmer J; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
  • Sacks R; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
  • Harvey RJ; Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, UNSW, Sydney, Australia.
Rhinology ; 55(3): 234-241, 2017 09 01.
Article en En | MEDLINE | ID: mdl-28667737
BACKGROUND: Although extracellular matrix (ECM) proteins are associated with irreversible lower airway changes, the relationship with upper airway remodelling which occurs during chronic rhinosinusitis (CRS) is poorly understood. This study assessed the expression of ECM proteins periostin, fibulin-1, fibronectin and collagenIV in nasal mucosa of patients with and without histologic features of remodelling. METHODS: A cross-sectional study of sinonasal mucosal biopsies taken from patients, undergoing surgery for CRS was performed, where patients were grouped according to remodelling, defined by basement membrane thickening (BMT over 7.5 micrometer) and subepithelial fibrosis. An overall view and three random fields of immunostained tissue sections that included epithelium, basement membrane and submucosa, were imaged using Zeiss Zen software. The area and intensity of positive staining were scored by two blinded observers, using a 12-point ordinal scale of weak to strong. RESULTS: 65 patients (47.6 +/- 13.4years, 44.6% female) were assessed. Patients were grouped as controls 26.2%, BMT/no fibrosis 38.5% or BMT and fibrosis 33.8%. Stronger grade of periostin expression was associated with remodelling changes and tissue eosinophilia over 10/HPF. Fibulin-1, fibronectin and collagenIV did not differ. CONCLUSION: Periostin expression was associated with the presence of BMT, fibrosis and tissue eosinophilia and may identify patients undergoing remodelling changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinusitis / Biomarcadores / Moléculas de Adhesión Celular / Fibronectinas / Eosinófilos / Mucosa Nasal Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rhinology Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinusitis / Biomarcadores / Moléculas de Adhesión Celular / Fibronectinas / Eosinófilos / Mucosa Nasal Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rhinology Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos