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Dopamine transporter (DAT1/SLC6A3) polymorphism and the association between being born small for gestational age and symptoms of ADHD.
Waldie, K E; Cornforth, C M; Webb, R E; Thompson, J M D; Murphy, R; Moreau, D; Slykerman, R; Morgan, A R; Ferguson, L R; Mitchell, E A.
Afiliación
  • Waldie KE; School of Psychology, The University of Auckland, New Zealand. Electronic address: k.waldie@auckland.ac.nz.
  • Cornforth CM; The Institute for Disorders of Attention and Impulsivity, Developmental Brain Behaviour Laboratory, School of Psychology, The University of Southampton, UK; The Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
  • Webb RE; School of Psychology, The University of Auckland, New Zealand.
  • Thompson JMD; The Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
  • Murphy R; Department of Medicine, The University of Auckland, New Zealand.
  • Moreau D; School of Psychology, The University of Auckland, New Zealand.
  • Slykerman R; The Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
  • Morgan AR; Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
  • Ferguson LR; Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
  • Mitchell EA; The Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
Behav Brain Res ; 333: 90-97, 2017 08 30.
Article en En | MEDLINE | ID: mdl-28666839
Being small for gestational age (SGA) has been established as a risk factor for Attention Deficit Hyperactivity Disorder (ADHD). Likewise, several molecular genetic studies have found a link between DAT1 and ADHD. This study investigated whether SGA moderates the effect of dopamine transporter gene variants on the risk of ADHD. A total of 546 children of European descent were genotyped at age 11 for seven DAT1 SNPs (rs6347, rs11564774, rs40184, rs1042098, rs2702, rs8179029 and rs3863145). The Strengths and Difficulties Questionnaire was used to measure symptoms of ADHD at ages 3.5, 7 and 11. We found significant gene-environment interactions between birth weight and DAT1 SNPs (rs6347, rs40184, rs1042098, rs3863145) on ADHD symptoms at 3.5 years only. Results suggest that genotypic variation of DAT1 may confer a relative protective effect against ADHD in SGA individuals. This study supports the idea that being born SGA moderates the effect of the DAT1 gene on ADHD symptoms in the preschool years and may help to explain some of the heterogeneity in ADHD outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Edad Gestacional / Polimorfismo de Nucleótido Simple / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Interacción Gen-Ambiente Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Behav Brain Res Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Edad Gestacional / Polimorfismo de Nucleótido Simple / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Interacción Gen-Ambiente Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Behav Brain Res Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos