Your browser doesn't support javascript.
loading
Mice exposure to tannery effluents changes their olfactory capacity, and their response to predators and to the inhibitory avoidance test.
Mendes, Bruna de Oliveira; Rabelo, Letícia Martins; E Silva, Bianca Costa; de Souza, Joyce Moreira; da Silva Castro, André Luis; da Silva, Anderson Rodrigo; de Lima Rodrigues, Aline Sueli; Malafaia, Guilherme.
Afiliación
  • Mendes BO; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, Brazil.
  • Rabelo LM; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, Brazil.
  • E Silva BC; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, Brazil.
  • de Souza JM; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, Brazil.
  • da Silva Castro AL; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Urutaí, GO, Brazil.
  • da Silva AR; Laboratório de Estatística Experimental, Instituto Federal Goiano-Câmpus Urutaí, Urutaí, GO, Brazil.
  • de Lima Rodrigues AS; Departamento de Ciências Biológicas, Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Urutaí, GO, Brazil.
  • Malafaia G; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, Brazil. guilhermeifgoiano@gmail.com.
Environ Sci Pollut Res Int ; 24(23): 19234-19248, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28664498
The current study has assessed whether the oral and/or dermal exposure of C57Bl/6 J mice to tannery effluent (a complex pollutant consisting of xenobiotic mixtures) could damage their olfactory functions, as well as whether it changes their aversive behavior in the inhibitory avoidance test. Accordingly, the animals were distributed in groups which were exposed or not to this xenobiotic through two different routes (oral and dermal), for 15 days. The effluent group subjected to oral exposure received drinking water containing 5% tannery effluent, whereas the animals in the dermal group were exposed to raw tannery effluent for 1 h/day. The animals dermally exposed to the tannery effluent (males and females) have shown the highest latency to find palatable food in the buried food test. The shortest time spent by the animals (orally or dermally) exposed to tannery effluent in the safety zone of the apparatus used in the predator exposure test, as well as the longest time spent by them in the aversive zone, have shown failures in their perception to the risk represented by the presence of the predator (cat). The passive avoidance test results have shown that the dermal exposure to tannery effluent led to partial memory deficit in male and female mice; therefore, the present study has confirmed the tannery effluent toxicity to mammals. Moreover, the present study was pioneer in demonstrating that the dermal exposure to this xenobiotic, even for a short period-of-time, can change the olfactory and cognitive functions of animals, as well as lead to harmful consequences to their health.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Curtiembre / Contaminantes Químicos del Agua / Percepción Olfatoria / Residuos Industriales / Trastornos de la Memoria Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Curtiembre / Contaminantes Químicos del Agua / Percepción Olfatoria / Residuos Industriales / Trastornos de la Memoria Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania