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Natural history of t(11;14) multiple myeloma.
Lakshman, A; Alhaj Moustafa, M; Rajkumar, S V; Dispenzieri, A; Gertz, M A; Buadi, F K; Lacy, M Q; Dingli, D; Fonder, A L; Hayman, S R; Hobbs, M A; Gonsalves, W I; Hwa, Y L; Kapoor, P; Leung, N; Go, R S; Lin, Y; Kourelis, T V; Lust, J A; Russell, S J; Zeldenrust, S R; Kyle, R A; Kumar, S K.
Afiliación
  • Lakshman A; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Alhaj Moustafa M; Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
  • Rajkumar SV; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Dispenzieri A; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Gertz MA; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Buadi FK; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lacy MQ; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Dingli D; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Fonder AL; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Hayman SR; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Hobbs MA; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Gonsalves WI; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Hwa YL; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kapoor P; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Leung N; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Go RS; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lin Y; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kourelis TV; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lust JA; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Russell SJ; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Zeldenrust SR; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kyle RA; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kumar SK; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Leukemia ; 32(1): 131-138, 2018 01.
Article en En | MEDLINE | ID: mdl-28655925
Translocation (11;14) on interphase fluorescent in situ hybridization in plasma cells is regarded as a standard risk prognostic marker in multiple myeloma based on studies conducted before introduction of current therapies. We identified 365 patients with t(11;14), and 730 matched controls:132 patients with non-(11;14) translocations and 598 patients with no chromosomal translocation. The median progression-free survival for the three groups were 23.0 (95% confidence interval (CI), 20.8-27.6), 19.0 (95% CI, 15.8-22.7) and 28.3 (95% CI, 25.7-30.6) months, respectively (P<0.01). The median overall survival (OS) for t(11;14), non-(11;14) translocation and no-translocation groups were 74.4 (95% CI, 64.8-89.3), 49.8 (95% CI, 40.0-60.6) and 103.6 (95% CI, 85.2-112.3) months, respectively (P<0.01). Excluding those with 17p abnormality, the median OS in the three groups were 81.7 (95% CI, 67.0-90.7), 58.2 (95% CI, 47.0-76.4) and 108.3 (95% CI, 92.4-140.1) months, respectively (P<0.01). The above relationship held true in patients with age <65 years, international staging system (ISS) I/II stage or those who received novel agent-based induction. Advanced age (hazard ratio (HR): 1.98), 17p abnormality (HR: 2.2) and ISS III stage (HR: 1.59) at diagnosis predicted reduced OS in patients with t(11;14). These results suggest that outcomes of t(11;14) MM are inferior to other standard risk patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos / Mieloma Múltiple Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos / Mieloma Múltiple Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido