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Inorganic polyphosphate enhances radio-sensitivity in a human non-small cell lung cancer cell line, H1299.
Tsutsumi, Kaori; Matsuya, Yusuke; Sugahara, Tomoki; Tamura, Manami; Sawada, Satoshi; Fukura, Sagiri; Nakano, Hisashi; Date, Hiroyuki.
Afiliación
  • Tsutsumi K; 1 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
  • Matsuya Y; 2 Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
  • Sugahara T; 3 Sanda City Hospital, Sanda, Japan.
  • Tamura M; 4 School of Medicine, Hokkaido University, Sapporo, Japan.
  • Sawada S; 4 School of Medicine, Hokkaido University, Sapporo, Japan.
  • Fukura S; 2 Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
  • Nakano H; 5 Hiroshima Heiwa Clinic High-Precision Radiotherapy Center, Hiroshima, Japan.
  • Date H; 1 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Tumour Biol ; 39(6): 1010428317705033, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28651489
Inorganic polyphosphate is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. Polyphosphate has been recognized as a potent anti-metastasis reagent. However, the molecular mechanism underlying polyphosphate action on cancer cells is poorly understood. In this study, we investigated the involvement of polyphosphate in radio-sensitivity using a human non-small cell lung cancer cell line, H1299. We found that polyphosphate treatment decreases cellular adenosine triphosphate levels, suggesting a disruption of energy metabolism. We also found that the induction of DNA double-strand breaks was enhanced in polyphosphate-treated cells after X-ray irradiation and colony formation assay revealed that cell survival decreased compared with that of the control groups. These findings suggest that polyphosphate is a promising radio-sensitizer for cancer cells. Therefore, we hypothesized that polyphosphate treatment disrupts adenosine triphosphate-mediated energy transfer for cellular survival and DNA repair, thereby reducing the cellular capability to resist X-ray irradiation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Metástasis de la Neoplasia Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Metástasis de la Neoplasia Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos