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Idiopathic thrombocytopenic purpura: pathogenesis and potential therapeutic approach.
Zhao, Xiaohong; Qi, Xiaomei; Wang, Chen; Zhou, Zhonghao; Cao, Haiwu; Wu, Pin; Li, Linghao; Lu, Shiyun; Wang, Zhi.
Afiliación
  • Zhao X; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Qi X; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Wang C; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Zhou Z; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Cao H; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Wu P; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Li L; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Lu S; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China.
  • Wang Z; Department of Hematology, Wuxi Second People's Hospital, Nanjing Medical University, Wuxi, China - wangzhi102100@163.com.
Minerva Med ; 108(6): 502-506, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28643502
BACKGROUND: This study sought to clarify the pathogenesis of idiopathic thrombocytopenic purpura (ITP) and make preliminary investigations regarding a therapeutic approach. METHODS: Enzyme-linked immunosorbent assay was used to establish and analyze the standard curve for interferon (IFN) γ, interleukin (IL) 4, and IL-17 in order to determine a measurement method for these cytokines. Subsequently, cellular levels of IFN-γ, IL-4, and IL-17 in the peripheral blood of patients in the treatment group (traditional Chinese medicine) was compared with those in the control group (Western-style care). An ITP mice model was also established and treated with different medications. RESULTS: Th1/Th2 cell quantities in ITP patients were significantly higher than in healthy individuals (P<0.05). Furthermore, IL-17 secreted by Th17 cells was significantly higher in ITP patients than healthy individuals (P<0.01). A combination of traditional Chinese medicine and Western-style care yielded the best treatment effect for ITP mice, followed by Western medicine alone and then Chinese medicine alone. CONCLUSIONS: The experimental results suggested that Th17 cells may be more related to the pathogenesis of ITP, and that application of Western-style care supplemented by traditional Chinese medicine may yield a more optimal treatment for ITP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantago / Prednisona / Medicamentos Herbarios Chinos / Púrpura Trombocitopénica Idiopática Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Minerva Med Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantago / Prednisona / Medicamentos Herbarios Chinos / Púrpura Trombocitopénica Idiopática Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Minerva Med Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Italia