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Salivary epithelial-myoepithelial carcinoma: clinical, morphological and molecular features.
De Cecio, R; Cantile, M; Fulciniti, F; Botti, G; Foschini, M P; Losito, N S.
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  • De Cecio R; SC Anatomia Patologica e Citopatologia, Istituto Nazionale Tumori Fondazione "G. Pascale", Napoli, Italy.
  • Cantile M; SC Anatomia Patologica e Citopatologia, Istituto Nazionale Tumori Fondazione "G. Pascale", Napoli, Italy.
  • Fulciniti F; Istituto Cantonale di Patologia, Servizio di Citologia Clinica, Locarno, Switzerland.
  • Botti G; SC Anatomia Patologica e Citopatologia, Istituto Nazionale Tumori Fondazione "G. Pascale", Napoli, Italy.
  • Foschini MP; Department of Biomedical and Neuromotor Sciences, University of Bologna, Section of Anatomic Pathology "M. Malpighi", Department of Oncology, Bellaria Hospital, Bologna, Italy.
  • Losito NS; SC Anatomia Patologica e Citopatologia, Istituto Nazionale Tumori Fondazione "G. Pascale", Napoli, Italy.
Pathologica ; 109(1): 1-8, 2017 Mar.
Article en En | MEDLINE | ID: mdl-28635988
Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic tumor accounting for less than 2% of all salivary gland malignancies. It presents as a slowly growing, asymptomatic small size mass, with ulceration of overlying mucosa in some cases. Microscopically, it is characterized by glands lined by the simultaneous presence of two different cell components, inner epithelial cells and outer myoepithelial cells. Immunohistochemical staining of myoepithelial cells is variably positive for vimentin, Smooth Muscle Actin (SMA), Muscle Specific Actin (MSA), S100, Smooth Muscle Myosin Heavy Chain I(SM-MHC), calponin and p63. Several molecular alterations, mainly point mutations, have been described. Mutations of HRAS, AKT1, CTNNB1 and PIK3CA were highlighted in variable percentage of EMC samples. EMC is considered a low-grade malignant tumor with a 5-year survival rate of 94% that may commonly recur locally after resection in 30-50% of cases. At the moment, adequate resection with negative margins is the minimum recommended and necessary treatment.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma / Mioepitelioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pathologica Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma / Mioepitelioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pathologica Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia