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Manganese(I)-Catalyzed Regio- and Stereoselective 1,2-Diheteroarylation of Allenes: Combination of C-H Activation and Smiles Rearrangement.
Chen, Shi-Yong; Han, Xiang-Lei; Wu, Jia-Qiang; Li, Qingjiang; Chen, Yunyun; Wang, Honggen.
Afiliación
  • Chen SY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Han XL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Wu JQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li Q; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Chen Y; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
  • Wang H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Angew Chem Int Ed Engl ; 56(33): 9939-9943, 2017 08 07.
Article en En | MEDLINE | ID: mdl-28631868
Heteroarenes are important structural motif in functional molecules. A MnI -catalyzed 1,2-diheteroarylation of allenes via a C-H activation/Smiles rearrangement cascade is presented. The reaction occurred under additive-free or even solvent-free conditions, which allowed the creation of two C-C and one C-N bonds in a single operation. A series of structurally diverse bicyclic or tricyclic compounds bearing an exocyclic double bond were constructed in good to excellent efficiency. The decarboxylative ring-opening of the products led to the facile synthesis of vicinal biheteroaryls. Synthetic applications were demonstrated and preliminary mechanistic studies were conducted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania