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Antibacterial activity of crude extracts of some South African medicinal plants against multidrug resistant etiological agents of diarrhoea.
Bisi-Johnson, Mary A; Obi, Chikwelu L; Samuel, Babatunde B; Eloff, Jacobus N; Okoh, Anthony I.
Afiliación
  • Bisi-Johnson MA; Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria. jumokade@yahoo.co.uk.
  • Obi CL; Department of Medical Microbiology, Walter Sisulu University, Mthatha, 5117, South Africa. jumokade@yahoo.co.uk.
  • Samuel BB; SAMRC Microbial Water Quality, Monitoring Centre, University of Fort Hare, Alice, South Africa. jumokade@yahoo.co.uk.
  • Eloff JN; Directorate of Academic Affairs, University of Fort Hare, Alice, 5700, South Africa.
  • Okoh AI; SAMRC Microbial Water Quality, Monitoring Centre, University of Fort Hare, Alice, South Africa.
BMC Complement Altern Med ; 17(1): 321, 2017 Jun 19.
Article en En | MEDLINE | ID: mdl-28629407
BACKGROUND: This study evaluated the antibacterial activity of some plants used in folklore medicine to treat diarrhoea in the Eastern Cape Province, South Africa. METHODS: The acetone extracts of Acacia mearnsii De Wild., Aloe arborescens Mill., A. striata Haw., Cyathula uncinulata (Schrad.) Schinz, Eucomis autumnalis (Mill.) Chitt., E. comosa (Houtt.) Wehrh., Hermbstaedtia odorata (Burch. ex Moq.) T.Cooke, Hydnora africana Thunb, Hypoxis latifolia Wight, Pelargonium sidoides DC, Psidium guajava L and Schizocarphus nervosus (Burch.) van der Merwe were screened against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, multi-resistant Salmonella enterica serovar Isangi, S. typhi, S. enterica serovar Typhimurium, Shigella flexneri type 1b and Sh. sonnei phase II. A qualitative phytochemical screening of the plants extracts was by thin layer chromatography. Plants extracts were screened for antibacterial activity using serial dilution microplate technique and bioautography. RESULTS: The TLC fingerprint indicated the presence of terpenoids and flavonoids in the herbs. Most of the tested organisms were sensitive to the crude acetone extracts with minimum inhibitory concentration (MIC) values ranging from 0.018-2.5 mg/mℓ. Extracts of A. striata, C. uncinulata, E. autumnalis and P. guajava were more active against enteropathogens. S. aureus and Sh. flexneri were the most sensitive isolates to the crude extracts but of significance is the antibacterial activity of A. arborescens and P. guajava against a confirmed extended spectrum betalactamase positive S. enterica serovar Typhimurium. CONCLUSION: The presence of bioactive compounds and the antibacterial activity of some of the selected herbs against multidrug resistant enteric agents corroborate assertions by traditional healers on their efficacies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Bacterias / Infecciones Bacterianas / Extractos Vegetales / Farmacorresistencia Bacteriana Múltiple / Diarrea / Antibacterianos Tipo de estudio: Etiology_studies / Qualitative_research Límite: Humans País/Región como asunto: Africa Idioma: En Revista: BMC Complement Altern Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Bacterias / Infecciones Bacterianas / Extractos Vegetales / Farmacorresistencia Bacteriana Múltiple / Diarrea / Antibacterianos Tipo de estudio: Etiology_studies / Qualitative_research Límite: Humans País/Región como asunto: Africa Idioma: En Revista: BMC Complement Altern Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido