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The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue.
Davis, Richard J; Alam, Nazia M; Zhao, Cuiping; Müller, Claudia; Saini, Janmeet S; Blenkinsop, Timothy A; Mazzoni, Francesca; Campbell, Melissa; Borden, Susan M; Charniga, Carol J; Lederman, Patty L; Aguilar, Vanessa; Naimark, Michael; Fiske, Michael; Boles, Nathan; Temple, Sally; Finnemann, Silvia C; Prusky, Glen T; Stern, Jeffrey H.
Afiliación
  • Davis RJ; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Alam NM; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10605, USA; Center for Visual Restoration, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
  • Zhao C; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Müller C; Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx, NY 10458, USA.
  • Saini JS; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Blenkinsop TA; Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Mazzoni F; Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx, NY 10458, USA.
  • Campbell M; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Borden SM; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Charniga CJ; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Lederman PL; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Aguilar V; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Naimark M; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Fiske M; Upstate Stem Cell cGMP Facility, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Boles N; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Temple S; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Finnemann SC; Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx, NY 10458, USA.
  • Prusky GT; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10605, USA; Center for Visual Restoration, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
  • Stern JH; Neural Stem Cell Institute, Regenerative Research Foundation, One Discovery Drive, Rensselaer, NY 12144, USA. Electronic address: jeffreystern@neuralsci.org.
Stem Cell Reports ; 9(1): 42-49, 2017 07 11.
Article en En | MEDLINE | ID: mdl-28625537
Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We report that subretinal transplantation of RPE stem cell (RPESC)-derived RPE cells (RPESC-RPE) preserved vision in a rat model of RPE cell dysfunction. Importantly, the stage of differentiation that RPESC-RPE acquired prior to transplantation influenced the efficacy of vision rescue. Whereas cells at all stages of differentiation tested rescued photoreceptor layer morphology, an intermediate stage of RPESC-RPE differentiation obtained after 4 weeks of culture was more consistent at vision rescue than progeny that were differentiated for 2 weeks or 8 weeks of culture. Our results indicate that the developmental stage of RPESC-RPE significantly influences the efficacy of RPE cell replacement, which affects the therapeutic application of these cells for AMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Células Madre Adultas / Epitelio Pigmentado de la Retina / Degeneración Macular Límite: Animals / Humans Idioma: En Revista: Stem Cell Reports Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Células Madre Adultas / Epitelio Pigmentado de la Retina / Degeneración Macular Límite: Animals / Humans Idioma: En Revista: Stem Cell Reports Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos