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Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.
Jiang, Yan; Lin, Yan; Hu, Yi-Juan; Song, Xiao-Jun; Pan, Hong-Hua; Zhang, Hong-Jian.
Afiliación
  • Jiang Y; Dispensary of Traditional Chinese Medicine, Hangzhou First People's Hospital, 261 Huansha Road, Hangzhou, 310006, China.
  • Lin Y; Department of Pharmacy, Tongde Hospital of Zhejiang Province, 234 Gucui Road, Hangzhou, 310012, China.
  • Hu YJ; Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, 132 Tianmushan Road, Hangzhou, 310007, China.
  • Song XJ; Dispensary of Traditional Chinese Medicine, Hangzhou First People's Hospital, 261 Huansha Road, Hangzhou, 310006, China.
  • Pan HH; Department of Pharmacy, Tongde Hospital of Zhejiang Province, 234 Gucui Road, Hangzhou, 310012, China.
  • Zhang HJ; Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, 132 Tianmushan Road, Hangzhou, 310007, China. jian871211@sina.com.
BMC Complement Altern Med ; 17(1): 320, 2017 Jun 17.
Article en En | MEDLINE | ID: mdl-28623927
BACKGROUND: The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. METHODS: G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. RESULTS: G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. CONCLUSIONS: The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Quínico / Extractos Vegetales / Artritis Gotosa / Supresores de la Gota / Gnaphalium / Hiperuricemia / Antiinflamatorios Límite: Animals / Humans / Male Idioma: En Revista: BMC Complement Altern Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Quínico / Extractos Vegetales / Artritis Gotosa / Supresores de la Gota / Gnaphalium / Hiperuricemia / Antiinflamatorios Límite: Animals / Humans / Male Idioma: En Revista: BMC Complement Altern Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido