Ruthenium-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones.

Anil Kumar, K; Kannaboina, Prakash; Das, Parthasarathi

Anil Kumar, K; Kannaboina, Prakash; Das, Parthasarathi.

Afiliación

Anil Kumar K; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India. partha@iiim.ac.in.

Org Biomol Chem ; 15(26): 5457-5461, 2017 Jul 05.

Article en En | MEDLINE | ID: mdl-28621792

RESUMEN

An efficient Ru(ii)-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones in excellent yields. These designed arylated 2-pyridones and 1-isoquinolinones can serve as key structural motifs for accessing functionalized pyridines and isoquinolines.

Asunto(s)

Isoquinolinas/química; Piridonas/química; Rutenio/química; Catálisis; Estructura Molecular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Rutenio / Isoquinolinas Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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