Molindone and haloperidol in tardive dyskinesia.
J Clin Psychiatry
; 46(8 Pt 2): 4-7, 1985 Aug.
Article
en En
| MEDLINE
| ID: mdl-2862139
Preliminary results are described from a study of 11 outpatients manifesting exacerbated tardive dyskinesia after tapering and withdrawal of neuroleptic medications. Patients were randomly assigned to molindone or haloperidol under double-blind placebo-controlled conditions to compare the masking effects of the two drugs. Haloperidol treatment masked withdrawal-exacerbated tardive dyskinesia more than molindone did; this difference (measured by percent change in AIMS scores) was significant (p = .04) when the dose was 200% but not 100% of the prestudy neuroleptic dose. Despite several limitations to the study, the results suggest that molindone may have less dyskinetogenic potential than haloperidol. Further research in the area of site-specificity of molindone is indicated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Discinesia Inducida por Medicamentos
/
Haloperidol
/
Indoles
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Molindona
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Clin Psychiatry
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Estados Unidos