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Interleukin-24 inhibits osteosarcoma cell migration and invasion via the JNK/c-Jun signaling pathways.
Zhuo, Baobiao; Shi, Yingchun; Qin, Haihui; Sun, Qingzeng; Li, Zhengwei; Zhang, Fengfei; Wang, Rong; Wang, Xiaodong.
Afiliación
  • Zhuo B; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Shi Y; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Qin H; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Sun Q; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Li Z; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Zhang F; Department of Surgery, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, P.R. China.
  • Wang R; Department of Ultrasound, The Affiliated Hospital Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China.
  • Wang X; Department of Surgery, The Affiliated Children's Hospital of Soochow University, Suzhou, Jiangsu 221006, P.R. China.
Oncol Lett ; 13(6): 4505-4511, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28599451
Approximately 25% of osteosarcoma patients present with clinically detectable metastatic disease at the time of initial diagnosis. High-dose chemotherapy and/or surgery for the treatment of primary metastatic osteosarcoma is ineffective, and <20% of patients will survive 5 years from diagnosis. Therefore, the treatment of metastases is critical for the improvement of the prognosis of primary metastatic osteosarcoma patients. We have previously observed that overexpression of interleukin-24 (IL-24) inhibits neuroblastoma cell proliferation, migration and invasion in vitro. The present study investigated whether IL-24 may be a novel agent for osteosarcoma metastasis-suppressive treatment. It was observed that IL-24 is able to inhibit migration and invasion in spontaneously metastasizing human 143B osteosarcoma cells via the c-Jun N-terminal kinase (JNK)/c-Jun signaling pathway. IL-24 was effective in inhibiting JNK and c-Jun phosphorylation to downregulate matrix metalloproteinase (MMP)-2 and MMP-9, which contributed to the suppression of cell migration and invasion. It was concluded that IL-24 may be a potent agent in the inhibition of highly metastatic 143B osteosarcoma cells, and IL-24 may have translational potential as an effective therapeutic agent for the treatment of metastatic osteosarcoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2017 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2017 Tipo del documento: Article Pais de publicación: Grecia