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Eating behavior during dexamethasone treatment in children with acute lymphoblastic leukemia.
Warris, Lidewij T; van den Akker, Erica L T; Bierings, Marc B; van den Bos, Cor; Aarsen, Femke K; Zwaan, Michel C; Tissing, Wim J E; Veening, Margreet A; Pieters, Rob; van den Heuvel-Eibrink, Marry M.
Afiliación
  • Warris LT; Department of Pediatric Oncology, Erasmus MC Cancer Institute, Sophia Children's Hospital, Rotterdam, The Netherlands.
  • van den Akker ELT; Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Bierings MB; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • van den Bos C; Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Aarsen FK; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Zwaan MC; Department of Pediatric Hematology and Oncology, University Medical Center Utrecht-Wilhelmina Children's Hospital, Utrecht, The Netherlands.
  • Tissing WJE; Department of Pediatric Oncology, Academic Medical Center-Emma Children's Hospital, Amsterdam, The Netherlands.
  • Veening MA; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
  • Pieters R; Department of Pediatric Oncology, Erasmus MC Cancer Institute, Sophia Children's Hospital, Rotterdam, The Netherlands.
  • van den Heuvel-Eibrink MM; Department of Pediatric Hematology and Oncology, Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Pediatr Blood Cancer ; 64(12)2017 Dec.
Article en En | MEDLINE | ID: mdl-28598548
BACKGROUND AND AIM: Large prospective studies on dexamethasone-induced changes in eating behavior, energy, and nutrient intake are lacking in pediatric acute lymphoblastic leukemia (ALL). We prospectively studied eating behavior, energy, nutrient intake, and the effect on leptin and adiponectin levels during dexamethasone administration in children with ALL. PATIENTS: Parents of patients with ALL (3-16 years) completed a dietary diary for their child during 4 days of dexamethasone (6 mg/m2 ) administration. Energy intake and nutrient intake (energy percentage = E%) were assessed and compared with the recommended intake. The Dutch Eating Behavior Questionnaire for Children was completed before start and after 4 days of dexamethasone administration by patients of 7-12 years of age. Fasting leptin and adiponectin levels were also measured before start and after 4 days of dexamethasone administration. RESULTS: Energy intake per day(kcal) (N = 44) increased significantly during dexamethasone (median day 1: 1,103 (717-1,572) versus day 4: 1,482 (1,176-1,822), P < 0.01), including an increase in total protein, fat, saturated fat, carbohydrate, and sodium intake. Intake of saturated fat (median day 4: 12 E%) and salt (median day 4: 1.9 g/day) exceeded the healthy range for age and gender. With respect to eating behavior, dexamethasone significantly decreased restrained eating (P = 0.04). Leptin levels as well as adiponectin levels increased significantly during the dexamethasone course. CONCLUSIONS: Four days of dexamethasone treatment significantly increased energy intake, including excessive saturated fat and salt intake, and changed eating behavior in children with ALL. Nutritional and behavioral interventions during dexamethasone treatment are recommended to stimulate a healthy lifestyle.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dexametasona / Leucemia-Linfoma Linfoblástico de Células Precursoras / Conducta Alimentaria Tipo de estudio: Observational_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dexametasona / Leucemia-Linfoma Linfoblástico de Células Precursoras / Conducta Alimentaria Tipo de estudio: Observational_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos