Your browser doesn't support javascript.
loading
Cell Class-Dependent Intracortical Connectivity and Output Dynamics of Layer 6 Projection Neurons of the Rat Primary Visual Cortex.
Cotel, Florence; Fletcher, Lee N; Kalita-de Croft, Simon; Apergis-Schoute, John; Williams, Stephen R.
Afiliación
  • Cotel F; Queensland Brain Institute, The University of Queensland, Brisbane QLD, Australia.
  • Fletcher LN; Queensland Brain Institute, The University of Queensland, Brisbane QLD, Australia.
  • Kalita-de Croft S; Queensland Brain Institute, The University of Queensland, Brisbane QLD, Australia.
  • Apergis-Schoute J; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester, UK.
  • Williams SR; Queensland Brain Institute, The University of Queensland, Brisbane QLD, Australia.
Cereb Cortex ; 28(7): 2340-2350, 2018 07 01.
Article en En | MEDLINE | ID: mdl-28591797
Neocortical information processing is powerfully influenced by the activity of layer 6 projection neurons through control of local intracortical and subcortical circuitry. Morphologically distinct classes of layer 6 projection neuron have been identified in the mammalian visual cortex, which exhibit contrasting receptive field properties, but little information is available on their functional specificity. To address this we combined anatomical tracing techniques with high-resolution patch-clamp recording to identify morphological and functional distinct classes of layer 6 projection neurons in the rat primary visual cortex, which innervated separable subcortical territories. Multisite whole-cell recordings in brain slices revealed that corticoclaustral and corticothalamic layer 6 projection neurons exhibited similar somatically recorded electrophysiological properties. These classes of layer 6 projection neurons were sparsely and reciprocally synaptically interconnected, but could be differentiated by cell-class, but not target-cell-dependent rules of use-dependent depression and facilitation of unitary excitatory synaptic output. Corticoclaustral and corticothalamic layer 6 projection neurons were differentially innervated by columnar excitatory circuitry, with corticoclaustral, but not corticothalamic, neurons powerfully driven by layer 4 pyramidal neurons, and long-range pathways conveyed in neocortical layer 1. Our results therefore reveal projection target-specific, functionally distinct, streams of layer 6 output in the rodent neocortex.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Visual / Vías Visuales / Mapeo Encefálico / Red Nerviosa / Neuronas Límite: Animals Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Visual / Vías Visuales / Mapeo Encefálico / Red Nerviosa / Neuronas Límite: Animals Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos