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Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate.
Tao, Ran; Wang, Zhong-Feng; Qiu, Wei; He, Yu-Fang; Yan, Wei-Qun; Sun, Wen-Yi; Li, Hai-Jun.
Afiliación
  • Tao R; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
  • Wang ZF; Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
  • Qiu W; Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
  • He YF; Department of Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
  • Yan WQ; Institute of Phytochemistry, Jilin Academy of Chinese Medicine Sciences, Changchun, Jilin 130012, P.R. China.
  • Sun WY; Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
  • Li HJ; Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Exp Ther Med ; 13(6): 2812-2818, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28588665
The fifth most common cancer worldwide is hepatocellular carcinoma (HCC), which has an annual mortality rate of ~800,000. Although surgical procedures for HCC, such as hepatic resection and liver transplantation, have progressed and the outcomes of patients have improved, HCC is still characterized by frequent recurrence, even after liver transplantation. In the present study the expression of the protein coding gene, S100 calcium binding protein A3 (S100A3), was observed in 62 HCC tissues and tumor-surrounding tissues. The present study indicated that S100A3 activation was involved in tumorigenesis and tumor aggressiveness. The protein and mRNA expression levels of S100A3 in the human HCC cell line (HepG2) were investigated using western blotting and reverse transcription-quantitative polymerase chain reaction analysis, respectively. The function of sodium cantharidinate in inducing HCC cell apoptosis was also investigated. Sodium cantharidinate inhibited the protein and gene expression of S100A3 in HepG2 cells in vitro. These data suggested that S100A3 has an important role in human HCC. The present study indicates that the functional properties of sodium cantharidinate are promising for the development of a novel drug that may control the expression of S100A3 and improve the treatment of human HCC in the near future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exp Ther Med Año: 2017 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exp Ther Med Año: 2017 Tipo del documento: Article Pais de publicación: Grecia