Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway.

Liu, Xibao; Gong, Baijuan; de Souza, Lorena Brito; Ong, Hwei Ling; Subedi, Krishna P; Cheng, Kwong Tai; Swaim, William; Zheng, Changyu; Mori, Yasuo; Ambudkar, Indu S

Liu, Xibao; Gong, Baijuan; de Souza, Lorena Brito; Ong, Hwei Ling; Subedi, Krishna P; Cheng, Kwong Tai; Swaim, William; Zheng, Changyu; Mori, Yasuo; Ambudkar, Indu S.

Afiliación

Liu X; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Gong B; Department of Orthodontics, Jilin University School of Stomatology, Changchun 130021, People's Republic of China.
de Souza LB; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Ong HL; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Subedi KP; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Cheng KT; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Swaim W; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Zheng C; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Mori Y; Laboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Ambudkar IS; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. indu.ambudkar@nih.gov.

Sci Signal ; 10(482)2017 Jun 06.

Article en En | MEDLINE | ID: mdl-28588080

Asunto(s)

Canales de Calcio/metabolismo; Caspasa 3/metabolismo; Radioterapia/efectos adversos; Glándulas Salivales/patología; Glándulas Salivales/efectos de la radiación; Molécula de Interacción Estromal 1/metabolismo; Células Acinares/metabolismo; Células Acinares/patología; Células Acinares/efectos de la radiación; Animales; Calcio/metabolismo; Canales de Calcio/genética; Caspasa 3/genética; Células Cultivadas; Humanos; Potencial de la Membrana Mitocondrial/efectos de la radiación; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Mitocondrias/metabolismo; Mitocondrias/patología; Mitocondrias/efectos de la radiación; Proteína ORAI1/genética; Proteína ORAI1/metabolismo; Glándulas Salivales/metabolismo; Molécula de Interacción Estromal 1/genética; Canales Catiónicos TRPM/metabolismo; Rayos X

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioterapia / Glándulas Salivales / Canales de Calcio / Caspasa 3 / Molécula de Interacción Estromal 1 Límite: Animals / Humans Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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