FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.

Mottillo, Emilio P; Desjardins, Eric M; Fritzen, Andreas M; Zou, Vito Z; Crane, Justin D; Yabut, Julian M; Kiens, Bente; Erion, Derek M; Lanba, Adhiraj; Granneman, James G; Talukdar, Saswata; Steinberg, Gregory R

Mottillo, Emilio P; Desjardins, Eric M; Fritzen, Andreas M; Zou, Vito Z; Crane, Justin D; Yabut, Julian M; Kiens, Bente; Erion, Derek M; Lanba, Adhiraj; Granneman, James G; Talukdar, Saswata; Steinberg, Gregory R.

Afiliación

Mottillo EP; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.
Desjardins EM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.
Fritzen AM; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.
Zou VZ; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.
Crane JD; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.
Yabut JM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.
Kiens B; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.
Erion DM; Liver Disease Research, Takeda Pharmaceuticals, 35 Landsdowne Street, Cambridge, MA, 02139, USA.
Lanba A; Cardiovascular & Metabolic Diseases, Novartis Institute of Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Granneman JG; Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Talukdar S; Cardiometabolic Diseases, Merck Research Laboratories South San Francisco LLC, 630 Gateway Boulevard, South San Francisco, CA, 94080, USA.
Steinberg GR; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario, L8N 3Z5, Canada.

Mol Metab ; 6(6): 471-481, 2017 06.

Article en En | MEDLINE | ID: mdl-28580278

Asunto(s)

Acetil-CoA Carboxilasa/metabolismo; Factores de Crecimiento de Fibroblastos/farmacología; Glucosa/metabolismo; Proteínas Quinasas/metabolismo; Quinasas de la Proteína-Quinasa Activada por el AMP; Adipocitos/metabolismo; Animales; Homeostasis; Metabolismo de los Lípidos/efectos de los fármacos; Hígado/efectos de los fármacos; Hígado/metabolismo; Masculino; Ratones; Proteínas Quinasas/genética

Palabras clave

ACC; ACC DKI, ACC1-S79A and ACC2-S212A double knock-in; ACC, acetyl-CoA carboxylase; AKT, protein kinase B; AMPK; AMPK, AMP-activated protein kinase; Adipocyte; BAT, brown adipose tissue; Brown fat; CNS, central nervous system; COX, cytochrome c oxidase; CreERT2, Cre recombinase estrogen receptor T2; DAG, diacylglycerol; Diabetes; FFA, free fatty acid; FGF21; FGF21, fibroblast growth factor 21; FGFR1c, fibroblast growth factor receptor 1c; GTT, glucose tolerance test; H&E, hematoxylin and eosin; HFD, high fat diet; ITT, insulin tolerance test; KLB, beta klotho; NAFLD, non-alcoholic fatty liver disease; Obesity; RER, respiratory exchange ratio; TAG, triacylglycerol; UCP1, uncoupling protein 1; WAT, white adipose tissue; WT, wildtype; gWAT, gonadal white adipose tissue; iWAT, inguinal white adipose tissue; iß1ß2AKO, inducible AMPK ß1ß2 adipocyte knockout; mTORC1, mammalian target of rapamycin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Proteínas Quinasas / Factores de Crecimiento de Fibroblastos / Glucosa Límite: Animals Idioma: En Revista: Mol Metab Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania

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