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Electrohydrodynamic fabrication of core-shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment.
Reardon, Philip Jt; Parhizkar, Maryam; Harker, Anthony H; Browning, Richard J; Vassileva, Vessela; Stride, Eleanor; Pedley, R Barbara; Edirisinghe, Mohan; Knowles, Jonathan C.
Afiliación
  • Reardon PJ; Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute.
  • Parhizkar M; Department of Mechanical Engineering.
  • Harker AH; Department of Physics & Astronomy, University College London, London.
  • Browning RJ; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford.
  • Vassileva V; Department of Oncology, UCL Cancer Institute, University College London, London, UK.
  • Stride E; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford.
  • Pedley RB; Department of Oncology, UCL Cancer Institute, University College London, London, UK.
  • Edirisinghe M; Department of Mechanical Engineering.
  • Knowles JC; Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute.
Int J Nanomedicine ; 12: 3913-3926, 2017.
Article en En | MEDLINE | ID: mdl-28579777
Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control the distribution of CDDP within the particles, and high encapsulation efficiency (>70%) of the drug was achieved. NPs were produced with either a core-shell (CS) or a matrix (uniform) structure. It was shown that CS NPs had the most sustained release of the 2 formulations, demonstrating a slower linear release post initial "burst" and longer duration. The role of particle architecture on the rate of drug release in vitro was confirmed by fitting the experimental data with various kinetic models. This indicated that the release process was a simple diffusion mechanism. The CS NPs were effectively internalized into the endolysosomal compartments of cancer cells and demonstrated an increased cytotoxic efficacy (concentration of a drug that gives half maximal response [EC50] reaching 6.2 µM) compared to free drug (EC50 =9 µM) and uniform CDDP-distributed NPs (EC50 =7.6 µM) in vitro. Thus, these experiments indicate that engineering the structure of PLGA NPs can be exploited to control both the dosage and the release characteristics for improved clinical chemotherapy treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Cisplatino / Ácido Láctico / Nanopartículas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Nanomedicine Año: 2017 Tipo del documento: Article Pais de publicación: Nueva Zelanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Cisplatino / Ácido Láctico / Nanopartículas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Nanomedicine Año: 2017 Tipo del documento: Article Pais de publicación: Nueva Zelanda