BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe.

Bai, Zhaoshi; Gao, Meiqi; Zhang, Huijuan; Guan, Qi; Xu, Jingwen; Li, Yao; Qi, Huan; Li, Zhengqiang; Zuo, Daiying; Zhang, Weige; Wu, Yingliang

Bai, Zhaoshi; Gao, Meiqi; Zhang, Huijuan; Guan, Qi; Xu, Jingwen; Li, Yao; Qi, Huan; Li, Zhengqiang; Zuo, Daiying; Zhang, Weige; Wu, Yingliang.

Afiliación

Bai Z; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Gao M; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhang H; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Guan Q; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Xu J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Li Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Qi H; Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Li Z; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zuodaiying@163.com.
Zhang W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zhangweige2000@sina.com.
Wu Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: yingliang_1016@163.com.

Cancer Lett ; 402: 81-92, 2017 08 28.

Article en En | MEDLINE | ID: mdl-28576750

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Colchicina/metabolismo; Resistencia a Múltiples Medicamentos/efectos de los fármacos; Resistencia a Antineoplásicos/efectos de los fármacos; Imidazoles/farmacología; Neoplasias Pulmonares/tratamiento farmacológico; Mitosis/efectos de los fármacos; Paclitaxel/farmacología; Moduladores de Tubulina/farmacología; Tubulina (Proteína)/metabolismo; Células A549; Subfamilia B de Transportador de Casetes de Unión a ATP/antagonistas & inhibidores; Subfamilia B de Transportador de Casetes de Unión a ATP/metabolismo; Apoptosis/efectos de los fármacos; Proteínas Reguladoras de la Apoptosis/metabolismo; Sitios de Unión; Células CACO-2; Proteínas de Ciclo Celular/metabolismo; Supervivencia Celular/efectos de los fármacos; Colchicina/química; Relación Dosis-Respuesta a Droga; Puntos de Control de la Fase G2 del Ciclo Celular/efectos de los fármacos; Células HeLa; Células Hep G2; Humanos; Imidazoles/química; Imidazoles/metabolismo; Concentración 50 Inhibidora; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Células MCF-7; Simulación del Acoplamiento Molecular; Unión Proteica; Conformación Proteica; Factores de Tiempo; Tubulina (Proteína)/química

Palabras clave

Apoptosis-resistance; CBSIs; Mitotic catastrophe; Multidrug resistance; P-glycoprotein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Colchicina / Paclitaxel / Resistencia a Múltiples Medicamentos / Resistencia a Antineoplásicos / Moduladores de Tubulina / Imidazoles / Neoplasias Pulmonares / Mitosis / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Cancer Lett Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

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