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Prognostic impact of macrometastasis linear size in sentinel node biopsy for breast carcinoma.
Foschini, M P; Miglio, R; Quinn, C; Belgio, B; Regitnig, P; Bianchi, S; Nannini, R; Buerger, H; Kaya, H; Illyés, I; Kulka, J; Wells, C A; De Gaetano, J; Lipeniece-Karele, I; Cserni, G.
Afiliación
  • Foschini MP; Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology at Bellaria Hospital, University of Bologna, Bologna, Italy. Electronic address: mariapia.foschini@ausl.bologna.it.
  • Miglio R; Department of Statistical Sciences "Paolo Fortunati", University of Bologna, Bologna, Italy.
  • Quinn C; St Vincent's University Hospital, Dublin, Ireland.
  • Belgio B; Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology at Bellaria Hospital, University of Bologna, Bologna, Italy.
  • Regitnig P; Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.
  • Bianchi S; Division of Pathological Anatomy, Department of, Surgery and Translational Medicine, University of Florence, Florence, Italy.
  • Nannini R; Division of Anatomic Pathology, District Hospital, Imola, Bologna, Italy.
  • Buerger H; Institute of Pathology, Breast Cancer Center Paderborn, Husener Str.46a, 33098, Paderborn, Germany.
  • Kaya H; School of Medicine, Department of Pathology, Marmara University, Istanbul, Turkey.
  • Illyés I; 2nd Department of Pathology, Semmelweis University Budapest, Ülloiút 93, Budapest, 1091, Hungary.
  • Kulka J; 2nd Department of Pathology, Semmelweis University Budapest, Ülloiút 93, Budapest, 1091, Hungary.
  • Wells CA; Department of Pathology, University College London, Level 2, Rockefeller Building, 21, University Street, London, WC1E 6JJ, UK.
  • De Gaetano J; Department of Pathology, Mater Dei Hospital, Tal-Qroqq, Msida, MSD 2090, Malta.
  • Lipeniece-Karele I; Pathology Centre, Riga East Clinical University Hospital, Hipokrata St 2, Riga, LV-1038, Latvia.
  • Cserni G; Bács-Kiskun County Teaching Hospital, Nyiriut 38, Kecskemét, 6000, Hungary; Department of Pathology, University of Szeged, Allomás u. 1, Szeged, 6720, Hungary.
Eur J Surg Oncol ; 43(8): 1421-1427, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28576464
AIM: The aim of the present study was to evaluate the risk of axillary non-sentinel lymph-node metastases (ALN) in breast cancer patients presenting macrometastasis (Mac-m) in the sentinel lymph node (SN). MATERIALS AND METHODS: A retrospective series of 1464 breast cancers from patients who underwent ALN dissection following the diagnosis of Mac-m in the sentinel node (SN) was studied. In all the cases the MAC-m linear size was evaluated and correlated with presence or absence of non-SN ALN metastases. RESULTS: Non-SN metastases were detected in 644∖1464 cases (43.98%). The risk of further axillary metastases ranged from 20.2% (37/183) in cases with Mac-m between 2 and 2.9 mm, to 65.3% (262/401) in cases with Mac-m measuring > 10 mm. The risk of non-SN ALN metastases showed a 3% increase, parallel to each mm increment in SN metastasis size. The data evaluated with the receiver operating characteristic (ROC) curve showed that the Mac-m could be subdivided according to a new cut-off of 7 mm. pT1 tumours, with Mac-m < 7 mm had a risk of non-SN ALN metastases of <30%. Furthermore 109/127 of these (85.8%) had 3 or less non-SN ALN -metastases. CONCLUSIONS: The present data give a detailed description on the risk of non-SN ALN involvement, that may be useful in the evaluation of breast cancer patients. It is suggested that a Mac-m size of <7 mm is related to a low residual axillary disease burden in breast cancer patients with small (pT1) tumours.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biopsia del Ganglio Linfático Centinela / Metástasis Linfática Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biopsia del Ganglio Linfático Centinela / Metástasis Linfática Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido