Your browser doesn't support javascript.
loading
Evaluation of maternal serum hypoxia inducible factor-1α, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsia.
Alici Davutoglu, Ebru; Akkaya Firat, Asuman; Ozel, Aysegül; Yilmaz, Nevin; Uzun, Isil; Temel Yuksel, Ilkbal; Madazli, Riza.
Afiliación
  • Alici Davutoglu E; a Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty , Istanbul University , Istanbul , Turkey.
  • Akkaya Firat A; b Department of Medical Biochemistry, Cerrahpasa Medical Faculty , Istanbul University , Istanbul , Turkey.
  • Ozel A; a Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty , Istanbul University , Istanbul , Turkey.
  • Yilmaz N; a Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty , Istanbul University , Istanbul , Turkey.
  • Uzun I; c Department of Obstetrics and Gynecology, Faculty of Medicine , Trakya University , Edirne , Turkey.
  • Temel Yuksel I; d Department of Obstetrics and Gynecology , Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.
  • Madazli R; a Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty , Istanbul University , Istanbul , Turkey.
J Matern Fetal Neonatal Med ; 31(15): 1976-1982, 2018 Aug.
Article en En | MEDLINE | ID: mdl-28574293
OBJECTIVE: To determine the serum levels of HIF-1 α, progranulin, and syndecan-1 in preeclampsia (PE) and normal pregnancy, and to compare whether these markers demonstrate any difference between early-onset PE (EO-PE) and late-onset PE (LO-PE). METHODS: This cross-sectional study was conducted on 27 women with EO-PE, 27 women with LO-PE, and 26 healthy normotensive pregnant controls matched for gestational age. Maternal levels of serum HIF-1 α, progranulin, and syndecan-1 were measured with the use of an enzyme-linked immunosorbent assay kit. RESULTS: Statistical analysis revealed significant differences between the control and the PE groups in progranulin (p < .001) and syndecan-1 (p <.001) levels. There were no significant differences in the serum HIF-1 α levels between these groups (p= .069). When PE patients were evaluated by considering subgroups; statistical analysis revealed significant inter-group differences in all biomarkers. Serum progranulin levels were significantly higher in LO-PE compared with the other two groups (EO-PE versus LO-PE and LO-PE versus controls p = .000). Control group presented significantly higher syndecan-1 levels, than EO and LO-PE (p < .001). HIF-1 α levels positively correlated with progranulin levels (r = .439, p= .000). CONCLUSIONS: Serum progranulin may have potential to be used as a biomarker for the differentiation of EO-PE and LO-PE. The co-operative action between HIF-1 α and progranulin might play a key role in the pathogenesis of LO-PE. The predominant feature of LO-PE seems to be an inflammatory process, whereas in EO-PE placentation problem seems to be the main pathology.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Péptidos y Proteínas de Señalización Intercelular / Subunidad alfa del Factor 1 Inducible por Hipoxia / Sindecano-1 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Péptidos y Proteínas de Señalización Intercelular / Subunidad alfa del Factor 1 Inducible por Hipoxia / Sindecano-1 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido