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Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy.
Braun, Katharina; Bock, Jörg; Wainstock, Tamar; Matas, Emmanuel; Gaisler-Salomon, Inna; Fegert, Jörg; Ziegenhain, Ute; Segal, Menahem.
Afiliación
  • Braun K; Otto von Guericke University Magdeburg, Institute of Biology, Dept. Zoology/Developmental Neurobiology, Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral and Brain Sciences CBBS, Germany. Electronic address: katharina.braun@ovgu.de.
  • Bock J; Otto von Guericke University Magdeburg, Institute of Biology, PG Epigenetics & Structural Biology, Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral and Brain Sciences CBBS, Germany. Electronic address: joerg.bock@ovgu.de.
  • Wainstock T; Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 84105, Israel.
  • Matas E; Otto von Guericke University Magdeburg, Institute of Biology, Dept. Zoology/Developmental Neurobiology, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: emmanuel.matas@ovgu.de.
  • Gaisler-Salomon I; University of Haifa, Dept. of Psychology, Haifa 31905, Israel. Electronic address: igsalomon@psy.haifa.ac.il.
  • Fegert J; Universitätsklinikum Ulm, Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie, Steinhövelstraße 5, 89075 Ulm, Germany. Electronic address: joerg.fegert@uniklinik-ulm.de.
  • Ziegenhain U; Universitätsklinikum Ulm, Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie, Steinhövelstraße 5, 89075 Ulm, Germany. Electronic address: ute.ziegenhain@uniklinik-ulm.de.
  • Segal M; Weizmann Institute, Dept. of Neurobiology, Rehovot 76100, Israel. Electronic address: menahem.segal@weizmann.ac.il.
Neurosci Biobehav Rev ; 117: 281-296, 2020 10.
Article en En | MEDLINE | ID: mdl-28571876
This review focuses on the inter- and transgenerational effects of stress experience prior to and during gestation. We provide an overview of findings from studies in humans as well as in animal models on brain structural and physiological functions and on the development of cognitive and executive functions. We also discuss the concept of stress-induced (re-)programming in more detail by highlighting epigenetic mechanisms and particularly those affecting the development of monoaminergic transmitter systems, which constitute the brains reward system. As the majority of studies have focused on male individuals we will emphasize sex-specific differences in stress vulnerability and resilience. Finally, we offer some perspectives on the development of protective and therapeutic interventions in cognitive and emotional disturbances resulting from pre-conception and prenatal stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Neurosci Biobehav Rev Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Neurosci Biobehav Rev Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos