Antidiabetic Activity of Extract and Compounds from an Endophytic Fungus Nigrospora oryzae.
Drug Res (Stuttg)
; 67(5): 308-311, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-28561223
The fungal extract as well as the 3 biosynthetic compounds, (S)-(+)-2-cis-4-trans-abscisic acid (1), , 7'-hydroxy-abscisic acid (2) and 4-des-hydroxyl altersolanol A (3) from the endophytic fungus, Nigrospora oryzae, isolated from Combretum dolichopetalum leaf were investigated for their antidiabetic potential.The antidiabetic activity was determined in alloxan-induced diabetic mice by monitoring their fasting blood sugar for 9 h.The extract and the compounds (1-3) significantly (p<0.001) reduced the fasting blood sugar of the diabetic mice.The present study has shown that the biosynthetic products of the endophytic fungus, N. oryzae, exhibited strong antidiabetic activity. It has further shown that endophytic fungi could be an alternative source of novel compounds for management of diabetes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores Biológicos
/
Diabetes Mellitus Experimental
/
Endófitos
/
Hongos
/
Hipoglucemiantes
Límite:
Animals
Idioma:
En
Revista:
Drug Res (Stuttg)
Año:
2017
Tipo del documento:
Article
País de afiliación:
Nigeria
Pais de publicación:
Alemania