Your browser doesn't support javascript.
loading
Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.
Lee, Eunjee; Giovanello, Kelly S; Saykin, Andrew J; Xie, Fengchang; Kong, Dehan; Wang, Yue; Yang, Liuqing; Ibrahim, Joseph G; Doraiswamy, P Murali; Zhu, Hongtu.
Afiliación
  • Lee E; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Giovanello KS; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Saykin AJ; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Xie F; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Kong D; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Wang Y; School of Mathematical Sciences, Nanjing Normal University, Nanjing, China.
  • Yang L; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Ibrahim JG; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Doraiswamy PM; Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Zhu H; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alzheimers Dement (Amst) ; 8: 86-95, 2017.
Article en En | MEDLINE | ID: mdl-28560309
INTRODUCTION: The growing public threat of Alzheimer's disease (AD) has raised the urgency to quantify the degree of cognitive decline during the conversion process of mild cognitive impairment (MCI) to AD and its underlying genetic pathway. The aim of this article was to test genetic common variants associated with accelerated cognitive decline after the conversion of MCI to AD. METHODS: In 583 subjects with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI; ADNI-1, ADNI-Go, and ADNI-2), 245 MCI participants converted to AD at follow-up. We tested the interaction effects between individual single-nucleotide polymorphisms and AD diagnosis trajectory on the longitudinal Alzheimer's Disease Assessment Scale-Cognition scores. RESULTS: Our findings reveal six genes, including BDH1, ST6GAL1, RAB20, PDS5B, ADARB2, and SPSB1, which are directly or indirectly related to MCI conversion to AD. DISCUSSION: This genome-wide association study sheds light on a genetic mechanism of longitudinal cognitive changes during the transition period from MCI to AD.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Alzheimers Dement (Amst) Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Alzheimers Dement (Amst) Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos