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Flot2 promotes tumor growth and metastasis through modulating cell cycle and inducing epithelial-mesenchymal transition of hepatocellular carcinoma.
Wang, Cheng-Hao; Zhu, Xiao-Dong; Ma, De-Ning; Sun, Hui-Chuan; Gao, Dong-Mei; Zhang, Ning; Qin, Cheng-Dong; Zhang, Yuan-Yuan; Ye, Bo-Gen; Cai, Hao; Shi, Wen-Kai; Cao, Man-Qin; Tang, Zhao-You.
Afiliación
  • Wang CH; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Zhu XD; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
  • Ma DN; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Sun HC; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
  • Gao DM; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Zhang N; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
  • Qin CD; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Zhang YY; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
  • Ye BG; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Cai H; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
  • Shi WK; Department of Liver Surgery, Fudan University Shanghai Cancer Center, Cancer HospitalShanghai 200032, China.
  • Cao MQ; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityShanghai 200032, China.
  • Tang ZY; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of EducationShanghai 200032, China.
Am J Cancer Res ; 7(5): 1068-1083, 2017.
Article en En | MEDLINE | ID: mdl-28560058
Flotillin-2 (Flot2) is a highly conserved and ubiquitously expressed protein that resides on the cytoplasmic side of the cell membrane within specific cholesterol rich microdomains. Some studies have reported that overexpression of Flot2 is related to cancer progression. However, the role of Flot2 in hepatocellular carcinoma (HCC) remains unclarified. In this study, we aim to explore the correlation between Flot2 expression and HCC progression and the underlying mechanism. In the present study, overexpression of Flot2 in HCC tissues and cell lines was detected, and forced overexpression of Flot2 significantly promoted the proliferation, migration, invasion and metastasis of HCC in vitro and in vivo by modulating cell cycle and inducing EMT, which was mediated via up-regulation of Twist as a result of Raf/MEK/ERK1/2 pathway activation. In contrast, silencing Flot2 expression inhibited these biological processes. Furthermore, high expression of Flot2 was significantly correlated with poor prognosis of HCC patients after curative resection and is an independent risk factor. In conclusion, Flot2 promoted tumor growth and metastasis of HCC through modulating cell cycle and inducing EMT. The expression of Flot2 may play a key role in HCC progression and may be regarded as a potential poor prognostic marker for HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Am J Cancer Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Am J Cancer Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos