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Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
Nishiguchi, Gisele A; Rico, Alice; Tanner, Huw; Aversa, Robert J; Taft, Benjamin R; Subramanian, Sharadha; Setti, Lina; Burger, Matthew T; Wan, Lifeng; Tamez, Victoriano; Smith, Aaron; Lou, Yan; Barsanti, Paul A; Appleton, Brent A; Mamo, Mulugeta; Tandeske, Laura; Dix, Ina; Tellew, John E; Huang, Shenlin; Mathews Griner, Lesley A; Cooke, Vesselina G; Van Abbema, Anne; Merritt, Hanne; Ma, Sylvia; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Wang, Yingyun; Haling, Jacob R; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Jansen, Johanna M; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Lees, Emma; Shao, Wenlin; Stuart, Darrin D; Dillon, Michael P; Ramurthy, Savithri.
Afiliación
  • Nishiguchi GA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Rico A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Tanner H; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Aversa RJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Taft BR; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Subramanian S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Setti L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Burger MT; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Wan L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Tamez V; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Smith A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Lou Y; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Barsanti PA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Appleton BA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Mamo M; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Tandeske L; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Dix I; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG , Werk Klybeck, Postfach, CH-4002 Basel, Switzerland.
  • Tellew JE; Genomics Institute of the Novartis Research Foundation , 10675 John Hopkins Drive, San Diego, California 92121, United States.
  • Huang S; Genomics Institute of the Novartis Research Foundation , 10675 John Hopkins Drive, San Diego, California 92121, United States.
  • Mathews Griner LA; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Cooke VG; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Van Abbema A; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Merritt H; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Ma S; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Gampa K; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Feng F; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Yuan J; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Wang Y; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Haling JR; Genomics Institute of the Novartis Research Foundation , 10675 John Hopkins Drive, San Diego, California 92121, United States.
  • Vaziri S; Genomics Institute of the Novartis Research Foundation , 10675 John Hopkins Drive, San Diego, California 92121, United States.
  • Hekmat-Nejad M; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Jansen JM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Polyakov V; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Zang R; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Sethuraman V; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Amiri P; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Singh M; Oncology, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Lees E; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Shao W; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Stuart DD; Oncology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Dillon MP; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Ramurthy S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
J Med Chem ; 60(12): 4869-4881, 2017 06 22.
Article en En | MEDLINE | ID: mdl-28557458
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidas / 2,2'-Dipiridil / Proteínas ras / Quinasas raf / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzamidas / 2,2'-Dipiridil / Proteínas ras / Quinasas raf / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos