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Poor peripheral blood stem cell mobilization affects long-term outcomes in multiple myeloma patients undergoing autologous stem cell transplantation.
Moreb, Jan S; Byrne, Michael; Shugarman, Ilicia; Zou, Fei; Xiong, Sican; May, William S; Norkin, Maxim; Hiemenz, John; Brown, Randall; Cogle, Christopher; Wingard, John R; Hsu, Jack W.
Afiliación
  • Moreb JS; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Byrne M; Division of Hematology/Oncology and Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, Tennessee.
  • Shugarman I; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Zou F; Biostatistics, University of Florida, Gainesville, Florida.
  • Xiong S; Biostatistics, University of Florida, Gainesville, Florida.
  • May WS; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Norkin M; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Hiemenz J; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Brown R; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Cogle C; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Wingard JR; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
  • Hsu JW; Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
J Clin Apher ; 33(1): 29-37, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28556233
BACKGROUND: Peripheral blood stem cell (PBSC) mobilization is routinely undertaken prior to autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). A number of studies have identified risk factors for poor PBSC mobilization, however, little data exists to correlate mobilization with disease-specific outcomes in this patient population. Prospective work in MM has demonstrated similar outcomes in a homogenous patient population. METHODS: In this single institution analysis, we retrospectively studied the impact of poor PBSC mobilization on progression free survival (PFS) and OS in MM patients undergoing PBSC mobilization. Poor mobilizers are defined as patients that collected < 4 × 106 CD34+ cells/kg over maximum of 5 apheresis days, or those that required ≥2 mobilization cycles to achieve this target. RESULTS: We confirm that poor PBSC mobilization is significantly associated with a shortened PFS (P = .0012) and OS (P = .0005) compared with good mobilizers. Our univariate analysis also shows that independent risk factors for poor mobilization include male gender, higher ideal body weight, and a greater median number of lines of chemotherapy prior to PBSC mobilization. However, by multivariate analysis, only number of prior lines of chemotherapy remains significantly predictive of poor mobilization (Odds ratio 1.857, P = .0095). The use of high-dose G-CSF (> 10 mcg/kg/day) and/or plerixafor can significantly improve mobilization and ASCT chances in this population. DISCUSSION: These data indicate that poor mobilization can be predictable and is associated with more aggressive disease biology and worse outcomes, warranting intensive post-ASCT management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movilización de Célula Madre Hematopoyética / Trasplante de Células Madre de Sangre Periférica / Mieloma Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movilización de Célula Madre Hematopoyética / Trasplante de Células Madre de Sangre Periférica / Mieloma Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos