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ER-mitochondria signaling regulates autophagy.
Gomez-Suaga, Patricia; Paillusson, Sebastien; Miller, Christopher C J.
Afiliación
  • Gomez-Suaga P; a Department of Basic and Clinical Neuroscience , Institute of Psychiatry, Psychology and Neuroscience, Kings College London , London , UK.
  • Paillusson S; a Department of Basic and Clinical Neuroscience , Institute of Psychiatry, Psychology and Neuroscience, Kings College London , London , UK.
  • Miller CCJ; a Department of Basic and Clinical Neuroscience , Institute of Psychiatry, Psychology and Neuroscience, Kings College London , London , UK.
Autophagy ; 13(7): 1250-1251, 2017 Jul 03.
Article en En | MEDLINE | ID: mdl-28548902
The endoplasmic reticulum (ER) and mitochondria form tight functional contacts that regulate several key cellular processes. The formation of these contacts involves "tethering proteins" that function to recruit regions of ER to mitochondria. The integral ER protein VAPB (VAMP associated protein B and C) binds to the outer mitochondrial membrane protein, RMDN3/PTPIP51 (regulator of microtubule dynamics 3) to form one such set of tethers. Recently, we showed that the VAPB-RMDN3 tethers regulate macroautophagy/autophagy. Small interfering RNA (siRNA) knockdown of VAPB or RMDN3 to loosen ER-mitochondria contacts stimulates autophagosome formation, whereas overexpression of VAPB or RMDN3 to tighten contacts inhibit their formation. Artificial tethering of ER and mitochondria via expression of a synthetic linker protein also reduces autophagy and this artificial tether rescues the effects of VAPB- or RMDN3-targeted siRNA loss on autophagosome formation. Finally, our studies revealed that the modulatory effects of ER-mitochondria contacts on autophagy involve their role in mediating ITPR (inositol 1,4,5-trisphosphate receptor) delivery of Ca2+ from ER stores to mitochondria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Retículo Endoplásmico / Mitocondrias Idioma: En Revista: Autophagy Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Retículo Endoplásmico / Mitocondrias Idioma: En Revista: Autophagy Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos