Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones.

Zhu, Xiao-Tong; Zhao, Qi; Liu, Feng; Wang, Ai-Fang; Cai, Pei-Jun; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo

Zhu, Xiao-Tong; Zhao, Qi; Liu, Feng; Wang, Ai-Fang; Cai, Pei-Jun; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo.

Afiliación

Zhu XT; School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 221116, P. R. China. jiangchem@jsnu.edu.cn laotu@jsnu.edu.cn.

Chem Commun (Camb) ; 53(51): 6828-6831, 2017 Jun 22.

Article en En | MEDLINE | ID: mdl-28548155

RESUMEN

A new silver-mediated 5-exo-dig cyclization of 2-alkynylbenzonitriles with disubstituted phosphine oxide and H2O has been developed. The reaction enables multiple bond-forming events including C-P, C-C and C-O bonds under atmospheric conditions, leading to the concise and direct formation of 28 examples of phosphorus-containing 1-indenones with generally good yields.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido

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