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High serum levels of soluble interleukin-2 receptor (sIL2-R), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF) are associated with adverse clinical features and predict poor outcome in diffuse large B-cell lymphoma.
Dlouhy, Ivan; Filella, Xavier; Rovira, Jordina; Magnano, Laura; Rivas-Delgado, Alfredo; Baumann, Tycho; Martínez-Trillos, Alejandra; Balagué, Olga; Martínez, Antonio; González-Farre, Blanca; Karube, Kennosuke; Gine, Eva; Delgado, Julio; Campo, Elías; López-Guillermo, Armando.
Afiliación
  • Dlouhy I; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain. Electronic address: idlouhy@clinic.ub.es.
  • Filella X; Department of Biochemistry and Molecular Genetics, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Rovira J; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Magnano L; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Rivas-Delgado A; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Baumann T; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Martínez-Trillos A; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Balagué O; Hematopathology Unit, Hospital Clínic, August Pi and Sunyer Biomedical Investigation Center (IDIBAPS), Villarroel St. 170, 08036 Barcelona, Spain.
  • Martínez A; Hematopathology Unit, Hospital Clínic, August Pi and Sunyer Biomedical Investigation Center (IDIBAPS), Villarroel St. 170, 08036 Barcelona, Spain.
  • González-Farre B; Hematopathology Unit, Hospital Clínic, August Pi and Sunyer Biomedical Investigation Center (IDIBAPS), Villarroel St. 170, 08036 Barcelona, Spain.
  • Karube K; Cell Biology & Pathology Department, University of the Ryukyus Graduate School of Medicine, 207 Uehara, Nishihara, Okinawa, Japan.
  • Gine E; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Delgado J; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
  • Campo E; Hematopathology Unit, Hospital Clínic, August Pi and Sunyer Biomedical Investigation Center (IDIBAPS), Villarroel St. 170, 08036 Barcelona, Spain.
  • López-Guillermo A; Department of Hematology, Hospital Clinic, Villarroel St. 170, 08036 Barcelona, Spain.
Leuk Res ; 59: 20-25, 2017 08.
Article en En | MEDLINE | ID: mdl-28544905
Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with heterogeneous outcomes. To improve accuracy of the international prognostic index score, new biological variables are being investigated. The aim of this study was to determine the prognostic significance of serum levels of different cytokines, namely soluble interleukin-2 receptor (sIL2-R), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF). We analyzed 197 de novo DLBCL patients (91 M/106 F; median age 66 years) treated with immunochemotherapy in a single institution. Serum cytokine determination was performed with ELISA, using the upper normal values as cut-offs. sIL-2R, IL-6 and TNF were elevated in 133, 130 and 144 cases, respectively. Elevation of each of these cytokines correlated with worse performance status, presence of B symptoms, advanced stage, elevated LDH and ß2-microglobulin (P<0.03) and lower complete remission rate (P<0.001). Elevated levels of serum sIL-2R and TNF were significantly associated with shorter progression-free (PFS) and overall survival (OS), while elevated IL-6 only with shorter PFS. Early death (<4months from diagnosis) strongly correlated with elevated cytokines. Determination of serum cytokines levels is simple and adds information regarding risk of early death, response to therapy, and outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Interleucina-2 / Linfoma de Células B Grandes Difuso / Interleucina-6 / Factor de Necrosis Tumoral alfa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Interleucina-2 / Linfoma de Células B Grandes Difuso / Interleucina-6 / Factor de Necrosis Tumoral alfa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido