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Intranasal distribution and clearance of thermoreversible gel in an animal model.
Choi, Ji Eun; Kim, Ki Ryung; Noh, Yangseop; Chung, Won-Ho; Cho, Yang-Sun; Chung, Seung-Kyu; Dhong, Hun-Jong; Kim, Hyo Yeol.
Afiliación
  • Choi JE; Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Kim KR; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Noh Y; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Chung WH; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Cho YS; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Chung SK; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Dhong HJ; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
  • Kim HY; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
Int Forum Allergy Rhinol ; 7(7): 705-711, 2017 07.
Article en En | MEDLINE | ID: mdl-28544659
BACKGROUND: Poloxamer 407 (P407) has been investigated for an intranasal drug delivery system. However, there is little known about the distribution and clearance of intranasally applied P407. The purpose of this study was to evaluate the distribution and clearance time of P407 in an animal model. METHODS: Five male pigs were administered the experimental solution (18% of P407 with 0.01% of fluorescein) and the control solution (normal saline with 0.01% of fluorescein) into their right and left nasal cavity, respectively. For quantitative analysis, endoscopic images of each nasal cavity were taken immediately and at 10, 20, 30, and 60 minutes after intranasal administration. RESULTS: The experimental group showed a significantly wider distribution of fluorescein than the control group at 10, 20, and 30 minutes. The experimental group also showed a significantly higher mean intensity of fluorescein than the control group at 10, 20, and 30 minutes. The mean intensity in the control group was significantly decreased during 30 minutes but the mean intensity in the experimental group was significantly decreased during 60 minutes. CONCLUSION: A substantial amount of P407 remained in the nasal cavity for at least 30 minutes post-application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tensoactivos / Poloxámero / Cavidad Nasal Límite: Animals / Humans / Male Idioma: En Revista: Int Forum Allergy Rhinol Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tensoactivos / Poloxámero / Cavidad Nasal Límite: Animals / Humans / Male Idioma: En Revista: Int Forum Allergy Rhinol Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos