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Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors.
Fang, Zhen; Wang, Tian-Qi; Li, Hui; Zhang, Guo; Wu, Xiao-Ai; Yang, Li; Peng, Yu-Lan; Zou, Jun; Li, Lin-Li; Xiang, Rong; Yang, Sheng-Yong.
Afiliación
  • Fang Z; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Wang TQ; Department of Clinical Medicine, School of Medicine, Nankai University, Tianjin 300071, China.
  • Li H; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Zhang G; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China.
  • Wu XA; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Yang L; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Peng YL; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Zou J; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Li LL; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China.
  • Xiang R; Department of Clinical Medicine, School of Medicine, Nankai University, Tianjin 300071, China. Electronic address: rxiang@nankai.edu.cn.
  • Yang SY; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: yangsy@scu.edu.cn.
Bioorg Med Chem Lett ; 27(14): 3201-3204, 2017 07 15.
Article en En | MEDLINE | ID: mdl-28539219
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Histona Demetilasas con Dominio de Jumonji / Nitrilos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Histona Demetilasas con Dominio de Jumonji / Nitrilos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido