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Zika virus evolution and spread in the Americas.
Metsky, Hayden C; Matranga, Christian B; Wohl, Shirlee; Schaffner, Stephen F; Freije, Catherine A; Winnicki, Sarah M; West, Kendra; Qu, James; Baniecki, Mary Lynn; Gladden-Young, Adrianne; Lin, Aaron E; Tomkins-Tinch, Christopher H; Ye, Simon H; Park, Daniel J; Luo, Cynthia Y; Barnes, Kayla G; Shah, Rickey R; Chak, Bridget; Barbosa-Lima, Giselle; Delatorre, Edson; Vieira, Yasmine R; Paul, Lauren M; Tan, Amanda L; Barcellona, Carolyn M; Porcelli, Mario C; Vasquez, Chalmers; Cannons, Andrew C; Cone, Marshall R; Hogan, Kelly N; Kopp, Edgar W; Anzinger, Joshua J; Garcia, Kimberly F; Parham, Leda A; Ramírez, Rosa M Gélvez; Montoya, Maria C Miranda; Rojas, Diana P; Brown, Catherine M; Hennigan, Scott; Sabina, Brandon; Scotland, Sarah; Gangavarapu, Karthik; Grubaugh, Nathan D; Oliveira, Glenn; Robles-Sikisaka, Refugio; Rambaut, Andrew; Gehrke, Lee; Smole, Sandra; Halloran, M Elizabeth; Villar, Luis; Mattar, Salim.
Afiliación
  • Metsky HC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Matranga CB; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Wohl S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Schaffner SF; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Freije CA; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Winnicki SM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • West K; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Qu J; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
  • Baniecki ML; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Gladden-Young A; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Lin AE; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Tomkins-Tinch CH; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Ye SH; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Park DJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Luo CY; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Barnes KG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Shah RR; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Chak B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Barbosa-Lima G; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Delatorre E; Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Vieira YR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Paul LM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Tan AL; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Barcellona CM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Porcelli MC; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Vasquez C; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
  • Cannons AC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Cone MR; Harvard University Extension School, Cambridge, Massachusetts, USA.
  • Hogan KN; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Kopp EW; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
  • Anzinger JJ; National Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
  • Garcia KF; Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Parham LA; National Institute of Infectious Diseases Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ramírez RMG; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
  • Montoya MCM; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
  • Rojas DP; Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA.
  • Brown CM; Miami-Dade County Mosquito Control, Miami, Florida, USA.
  • Hennigan S; Miami-Dade County Mosquito Control, Miami, Florida, USA.
  • Sabina B; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
  • Scotland S; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
  • Gangavarapu K; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
  • Grubaugh ND; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, Florida, USA.
  • Oliveira G; Department of Microbiology, The University of the West Indies, Mona, Kingston, Jamaica.
  • Robles-Sikisaka R; Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
  • Rambaut A; Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
  • Gehrke L; Grupo de Epidemiología Clínica, Universidad Industrial de Santander, Bucaramanga, Colombia.
  • Smole S; Grupo de Epidemiología Clínica, Universidad Industrial de Santander, Bucaramanga, Colombia.
  • Halloran ME; Department of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
  • Villar L; Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
  • Mattar S; Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.
Nature ; 546(7658): 411-415, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28538734
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Virus Zika / Infección por el Virus Zika Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans País/Región como asunto: America central / America do norte / America do sul / Brasil / Caribe / Colombia / Honduras / Puerto rico Idioma: En Revista: Nature Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Virus Zika / Infección por el Virus Zika Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans País/Región como asunto: America central / America do norte / America do sul / Brasil / Caribe / Colombia / Honduras / Puerto rico Idioma: En Revista: Nature Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido