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Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages.
Benke, Bahiru Punja; Aich, Pulakesh; Kim, Younghoon; Kim, Kyung Lock; Rohman, Md Rumum; Hong, Soonsang; Hwang, In-Chul; Lee, Eun Hui; Roh, Joon Ho; Kim, Kimoon.
Afiliación
  • Benke BP; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Aich P; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Kim Y; Department of Chemistry, Pohang University of Science and Technology , Pohang 37673, Republic of Korea.
  • Kim KL; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Rohman MR; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Hong S; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Hwang IC; Department of Chemistry, Pohang University of Science and Technology , Pohang 37673, Republic of Korea.
  • Lee EH; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
  • Roh JH; Department of Physiology, College of Medicine, The Catholic University of Korea , Seoul 06591, Republic of Korea.
  • Kim K; Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
J Am Chem Soc ; 139(22): 7432-7435, 2017 06 07.
Article en En | MEDLINE | ID: mdl-28538099
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos