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Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions.
Mallick, Pankajini; Taneja, Guncha; Moorthy, Bhagavatula; Ghose, Romi.
Afiliación
  • Mallick P; a Department of Pharmacological and Pharmaceutical Sciences , University of Houston , Houston , TX , USA.
  • Taneja G; a Department of Pharmacological and Pharmaceutical Sciences , University of Houston , Houston , TX , USA.
  • Moorthy B; b Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA.
  • Ghose R; a Department of Pharmacological and Pharmaceutical Sciences , University of Houston , Houston , TX , USA.
Expert Opin Drug Metab Toxicol ; 13(6): 605-616, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28537216
INTRODUCTION: Drug-metabolizing enzymes (DMEs) are primarily down-regulated during infectious and inflammatory diseases, leading to disruption in the metabolism of small molecule drugs (smds), which are increasingly being prescribed therapeutically in combination with biologics for a number of chronic diseases. The biologics may exert pro- or anti-inflammatory effect, which may in turn affect the expression/activity of DMEs. Thus, patients with infectious/inflammatory diseases undergoing biologic/smd treatment can have complex changes in DMEs due to combined effects of the disease and treatment. Areas covered: We will discuss clinical biologics-SMD interaction and regulation of DMEs during infection and inflammatory diseases. Mechanistic studies will be discussed and consequences on biologic-small molecule combination therapy on disease outcome due to changes in drug metabolism will be highlighted. Expert opinion: The involvement of immunomodulatory mediators in biologic-SMDs is well known. Regulatory guidelines recommend appropriate in vitro or in vivo assessments for possible interactions. The role of cytokines in biologic-SMDs has been documented. However, the mechanisms of drug-drug interactions is much more complex, and is probably multi-factorial. Studies aimed at understanding the mechanism by which biologics effect the DMEs during inflammation/infection are clinically important.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Regulación de la Expresión Génica / Enzimas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Expert Opin Drug Metab Toxicol Asunto de la revista: METABOLISMO / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Regulación de la Expresión Génica / Enzimas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Expert Opin Drug Metab Toxicol Asunto de la revista: METABOLISMO / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido