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Body mass index is inversely associated with arterial stiffness in Chinese adults with primary hypertension: results from the China Stroke Primary Prevention Trial (CSPPT).
Momin, Mohetaboer; Li, Jian-Ping; Zhang, Yan; Fan, Fang-Fang; Xu, Xi-Ping; Xu, Xin; Wang, Bin-Yan; Yang, Wen-Bin; Xie, Li-Ling; Huo, Yong.
Afiliación
  • Momin M; a Department of Cardiovascular Diseases , Peking University First Hospital , Beijing , China.
  • Li JP; a Department of Cardiovascular Diseases , Peking University First Hospital , Beijing , China.
  • Zhang Y; a Department of Cardiovascular Diseases , Peking University First Hospital , Beijing , China.
  • Fan FF; a Department of Cardiovascular Diseases , Peking University First Hospital , Beijing , China.
  • Xu XP; b National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division , Nanfang Hospital, Southern Medical University , Guangzhou , China.
  • Xu X; b National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division , Nanfang Hospital, Southern Medical University , Guangzhou , China.
  • Wang BY; b National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division , Nanfang Hospital, Southern Medical University , Guangzhou , China.
  • Yang WB; c Institute for Biomedicine , Anhui Medical University , Hefei , China.
  • Xie LL; c Institute for Biomedicine , Anhui Medical University , Hefei , China.
  • Huo Y; a Department of Cardiovascular Diseases , Peking University First Hospital , Beijing , China.
Clin Exp Hypertens ; 39(5): 394-401, 2017.
Article en En | MEDLINE | ID: mdl-28534657
BACKGROUND: This study aimed to elucidate the relationship between body mass index (BMI) and the presence of arterial stiffness in rural-dwelling Chinese adults with primary hypertension. METHODS: Primary hypertension patients (n = 19,375) receiving an average of 4.5 years of antihypertension therapy were selected from the Chinese Stroke Primary Prevention Trial (mean age: 64.7 ± 7.4 years, male: 37.8%). Anthropometric, demographic, hemodynamic, and biochemical data were obtained. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV). RESULTS: BMI was inversely associated with baPWV after adjusting for gender, age, smoking, alcohol consumption, center, pulse, SBP, DBP, FBG, TC, TG, HDL-C, BUN, Scr, UA, HCY, antidiabetes treatment, lipid-lowing treatment, and antihypertensive treatment (ß (SE): -10.72 (0.69), P < 0.0001). Quintile1 (Q1) was used as a reference; Q2, Q3, Q4, and Q5 groups were all inversely associated with baPWV. The ß increased with increasing BMI, ß (SE) was -20.29 (6.74), -30.66 (7.01), -51.82 (7.27), and -103.1 (7.62), respectively, for Q2 - Q5, P < 0.05. BMI remained inversely correlated with baPWV across differences in gender, center, blood pressure, lipid levels, and the presence or absence of diabetes subgroups. CONCLUSION: Increased BMI is a positive factor against the development of arterial stiffness in Chinese rural-dwelling adults with primary hypertension undergoing antihypertension treatments, after adjusting for confounding factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Índice de Masa Corporal / Rigidez Vascular / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Exp Hypertens Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Índice de Masa Corporal / Rigidez Vascular / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Exp Hypertens Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido