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A facile one-step method for preparation of Fe3O4/CS/INH nanoparticles as a targeted drug delivery for tuberculosis.
Zhao, Chili; Liu, Xun; Zhang, Xia; Yan, Hong; Qian, Zhilei; Li, Xinghui; Ma, Zhenye; Han, Qiaorong; Pei, Chonghua.
Afiliación
  • Zhao C; School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu Province 210046, China.
  • Liu X; State Key Laboratory Cultivation Base for Nonmetal Composite and Functional Materials,Southwest University of Science and Technology, Mianyang 621010, China.
  • Zhang X; Nanjing Chest Hospital, Nanjing, Jiangsu Province 210097, PR China.
  • Yan H; Nanjing Chest Hospital, Nanjing, Jiangsu Province 210097, PR China.
  • Qian Z; Nanjing Chest Hospital, Nanjing, Jiangsu Province 210097, PR China.
  • Li X; School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu Province 210046, China.
  • Ma Z; School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu Province 210046, China. Electronic address: 07197@njnu.edu.cn.
  • Han Q; School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu Province 210046, China. Electronic address: hanqiaorong@njnu.edu.cn.
  • Pei C; School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, Jiangsu Province 210046, China. Electronic address: peichonghua@swust.edu.cn.
Mater Sci Eng C Mater Biol Appl ; 77: 1182-1188, 2017 Aug 01.
Article en En | MEDLINE | ID: mdl-28531994
In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos