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Quantification of l-carvone in toothpastes available on the Swedish market.
Kroona, Liv; Warfvinge, Gunnar; Isaksson, Marléne; Ahlgren, Camilla; Dahlin, Jakob; Sörensen, Östen; Bruze, Magnus.
Afiliación
  • Kroona L; Department of Oral Pathology, Faculty of Odontology, Malmö University, 205 06, Malmö, Sweden.
  • Warfvinge G; Department of Oral Pathology, Faculty of Odontology, Malmö University, 205 06, Malmö, Sweden.
  • Isaksson M; Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
  • Ahlgren C; Department of Prosthodontics, Faculty of Odontology, Malmö University, 205 06, Malmö, Sweden.
  • Dahlin J; Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
  • Sörensen Ö; Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
  • Bruze M; Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
Contact Dermatitis ; 77(4): 224-230, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28524256
BACKGROUND: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. OBJECTIVES: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. METHODS: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. RESULTS: l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005-0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-carvone were found if limonene was listed on the label. CONCLUSION: The majority of toothpastes on the Swedish market contain l-carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pastas de Dientes / Monoterpenos Tipo de estudio: Etiology_studies Límite: Humans / Male País/Región como asunto: Europa Idioma: En Revista: Contact Dermatitis Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pastas de Dientes / Monoterpenos Tipo de estudio: Etiology_studies Límite: Humans / Male País/Región como asunto: Europa Idioma: En Revista: Contact Dermatitis Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido