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High-concentration glucose enhances invasion in invasive ductal breast carcinoma by promoting Glut1/MMP2/MMP9 axis expression.
Sun, Xian-Fu; Shao, Ying-Bo; Liu, Ming-Ge; Chen, Qi; Liu, Zhao-Jun; Xu, Bin; Luo, Su-Xia; Liu, Hui.
Afiliación
  • Sun XF; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Shao YB; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Liu MG; Department of Pathology, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Chen Q; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Liu ZJ; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Xu B; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Luo SX; Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
  • Liu H; Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.
Oncol Lett ; 13(5): 2989-2995, 2017 May.
Article en En | MEDLINE | ID: mdl-28521406
Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes for patients with T2DM. Increasing evidence reveals that a high concentration of glucose can promote tumor progression, while its role for migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains unclear. In the present study, it was demonstrated that IDBC patients with T2DM suffered an increased tumor size and more frequent lymphatic and distant metastasis compared with those without T2DM (P<0.05). MCF-7 breast carcinoma cells, which were cultured in a high glucose concentration medium (25.00 mM), exhibited increased invasion (P<0.05). In addition, the expression of glucose transporters (Gluts), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) in IDBC tissues with T2DM was significantly higher compared to those without T2DM. Downregulation of glucose transporter 1 (Glut1) by small interfering RNA may markedly suppress MCF-7 cell invasion as well as the expression of MMP2 and MMP9. These results suggest that T2DM can affect the malignant features of tumors in IDBC. The high glucose concentration in the tumor microenvironment may enhance IDBC invasion via upregulating Glut1/MMP2/MMP9 axis expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Oncol Lett Año: 2017 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Oncol Lett Año: 2017 Tipo del documento: Article Pais de publicación: Grecia