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Leishmanicidal Activity and Structure-Activity Relationships of Essential Oil Constituents.
Silva, Audrey R S T; Scher, Ricardo; Santos, Flaviane V; Ferreira, Sebastião R; Cavalcanti, Sócrates C H; Correa, Cristiane B; Bueno, Lilian L; Alves, Ricardo J; Souza, Damião P; Fujiwara, Ricardo T; Dolabella, Silvio S.
Afiliación
  • Silva ARST; Department of Pharmacy, Federal University of Sergipe, 49100-000 São Cristóvão, Sergipe, Brazil. audreytavares2@gmail.com.
  • Scher R; Laboratory of Molecular Biology of Pathogenic Bioagents, Department of Morphology, Federal University of Sergipe, 49100-000 São Cristóvão, Sergipe, Brazil. scher@ufs.br.
  • Santos FV; Laboratory of Molecular Biology of Pathogenic Bioagents, Department of Morphology, Federal University of Sergipe, 49100-000 São Cristóvão, Sergipe, Brazil. flavianevieirah@gmail.com.
  • Ferreira SR; Department of Parasitology, Biological Sciences Institute, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. ferreirasr2008@hotmail.com.
  • Cavalcanti SCH; Health Science Center, Federal University of Roraima, Av. Cap. Ene Garcez, 69310-000 Boa Vista, Roraima, Brazil. ferreirasr2008@hotmail.com.
  • Correa CB; Department of Pharmacy, Federal University of Sergipe, 49100-000 São Cristóvão, Sergipe, Brazil. socratescavalcanti@yahoo.com.br.
  • Bueno LL; Laboratory of Molecular Biology of Pathogenic Bioagents, Department of Morphology, Federal University of Sergipe, 49100-000 São Cristóvão, Sergipe, Brazil. crisbani@gmail.com.
  • Alves RJ; Department of Parasitology, Biological Sciences Institute, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. lilacerdabueno@gmail.com.
  • Souza DP; Department of Pharmaceutical Products, Federal University of Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. ricardodylan@farmacia.ufmg.br.
  • Fujiwara RT; Department of Pharmaceutical Sciences, Federal University of Paraíba, 58051-900 João Pessoa, Paraíba, Brazil. damiao_desousa@yahoo.com.br.
  • Dolabella SS; Department of Parasitology, Biological Sciences Institute, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. fujiwara@icb.ufmg.br.
Molecules ; 22(5)2017 May 16.
Article en En | MEDLINE | ID: mdl-28509873
Several constituents of essential oils have been shown to be active against pathogens such as bacteria, fungi, and protozoa. This study demonstrated the in vitro action of ten compounds present in essential oils against Leishmania amazonensis promastigotes. With the exception of p-cymene, all evaluated compounds presented leishmanicidal activity, exhibiting IC50 between 25.4 and 568.1 µg mL-1. Compounds with the best leishmanicidal activity presented a phenolic moiety (IC50 between 25.4 and 82.9 µg mL-1). Alicyclic alcohols ((-)-menthol and isoborneol) and ketones ((-)-carvone) promoted similar activity against the parasite (IC50 between 190.2 and 198.9 µg mL-1). Most of the compounds showed low cytotoxicity in L929 fibroblasts. Analysis of the structure-activity relationship of these compounds showed the importance of the phenolic structure for the biological action against the promastigote forms of the parasite.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania / Antiprotozoarios Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania / Antiprotozoarios Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza