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Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model.
Chang, Ru-Wen; Luo, Chien-Ming; Yu, Hsi-Yu; Chen, Yih-Sharng; Wang, Chih-Hsien.
Afiliación
  • Chang RW; Department of Physiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Ren'ai Rd., Zhongzheng Dist., Taipei, 10051, Taiwan.
  • Luo CM; Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, NO. 25, Lane 442, Sec. 1, Jingguo Rd., Hsin-Chu, 30059, Taiwan.
  • Yu HY; Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, NO. 25, Lane 442, Sec. 1, Jingguo Rd., Hsin-Chu, 30059, Taiwan.
  • Chen YS; Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei, 10002, Taiwan.
  • Wang CH; Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei, 10002, Taiwan.
BMC Cardiovasc Disord ; 17(1): 123, 2017 05 15.
Article en En | MEDLINE | ID: mdl-28506218
BACKGROUND: Extracorporeal life support (ECLS) systems are life-saving devices used for treating patients with severe cardiopulmonary failure. In this study, we implemented a rat model of ECLS without the administration of inotropes or vasopressors. METHODS: The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min. The right external jugular vein and right femoral artery were separately cannulated to the ECLS outflow and inflow, respectively. Thereafter, ECLS was terminated, wounds were closed, and mechanical ventilation was provided for another 90 min. Subsequently, blood gas and hemodynamic analyses were performed. The plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) were measured 120 min after reperfusion. RESULTS: The metabolic rate of lactate in the group of asphyxial cardiac arrest rescued by ECLS was slow; therefore, the pH at 120 min after reperfusion was significantly lower in this group than that in the group of normal rats treated with ECLS. The hemodynamic data showed no between-group differences. The plasma levels of CRP, IL-6, IL-10, and TNF-α increased after ECLS treatment. CONCLUSIONS: We successfully established a rodent ECLS model, which might be a useful approach for studying the pathophysiology induced by ECLS under clinical conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Puente Cardiopulmonar / Oxigenación por Membrana Extracorpórea / Arteria Femoral / Paro Cardíaco / Hemodinámica / Venas Yugulares Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Puente Cardiopulmonar / Oxigenación por Membrana Extracorpórea / Arteria Femoral / Paro Cardíaco / Hemodinámica / Venas Yugulares Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido