Your browser doesn't support javascript.
loading
Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging.
Gurung, Arati; Gates, Phillip E; Mazzaro, Luciano; Fulford, Jonathan; Zhang, Fuxing; Barker, Alex J; Hertzberg, Jean; Aizawa, Kunihiko; Strain, William D; Elyas, Salim; Shore, Angela C; Shandas, Robin.
Afiliación
  • Gurung A; Department of Bioengineering, University of Colorado Denver, Aurora, Colorado, USA.
  • Gates PE; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Mazzaro L; Department of Bioengineering, University of Colorado Denver, Aurora, Colorado, USA.
  • Fulford J; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Zhang F; Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
  • Barker AJ; Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
  • Hertzberg J; Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
  • Aizawa K; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Strain WD; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Elyas S; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Shore AC; Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, UK.
  • Shandas R; Department of Bioengineering, University of Colorado Denver, Aurora, Colorado, USA. Electronic address: Robin.Shandas@UCDenver.edu.
Ultrasound Med Biol ; 43(8): 1618-1627, 2017 08.
Article en En | MEDLINE | ID: mdl-28501327
Measurement of hemodynamic wall shear stress (WSS) is important in investigating the role of WSS in the initiation and progression of atherosclerosis. Echo particle image velocimetry (echo PIV) is a novel ultrasound-based technique for measuring WSS in vivo that has previously been validated in vitro using the standard optical PIV technique. We evaluated the repeatability and reproducibility of echo PIV for measuring WSS in the human common carotid artery. We measured WSS in 28 healthy participants (18 males and 10 females, mean age: 56 ± 12 y). Echo PIV was highly repeatable, with an intra-observer variability of 1.0 ± 0.1 dyn/cm2 for peak systolic (maximum), 0.9 dyn/cm2 for mean and 0.5 dyn/cm2 for end-diastolic (minimum) WSS measurements. Likewise, echo PIV was reproducible, with a low inter-observer variability (max: 2.0 ± 0.2 dyn/cm2, mean: 1.3 ± 0.1 dyn/cm2, end-diastolic: 0.7 dyn/cm2) and more variable inter-scan (test-retest) variability (max: 7.1 ± 2.3 dyn/cm2, mean: 2.9 ± 0.4 dyn/cm2, min: 1.5 ± 0.1 dyn/cm2). We compared echo PIV with the reference method, phase-contrast magnetic resonance imaging (PC-MRI); echo PIV-based WSS measurements agreed qualitatively with PC-MRI measurements (r = 0.89, p < 0.05). Significant differences were observed in some WSS measurements (echo PIV vs. PC-MRI): WSS at peak systole: 21 ± 7.0 dyn/cm2 vs. 15 ± 5.0 dyn/cm2; time-averaged WSS: 8.9 ± 3.0 dyn/cm2 vs. 7.1 ± 3.0 dyn/cm2 (p < 0.05); WSS at end diastole: 3.8 ± 2.8 dyn/cm2 vs. 3.9 ± 2 dyn/cm2 (p > 0.05). For the first time, we report that echo PIV can measure WSS with good repeatability and reproducibility in adult humans with a broad age range. Echo PIV is feasible in humans and offers an easy-to-use, ultrasound-based, quantitative technique for measuring WSS in vivo in humans with good repeatability and reproducibility.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reología / Procesamiento de Imagen Asistido por Computador / Imagen por Resonancia Magnética / Arterias Carótidas / Ultrasonografía Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Ultrasound Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reología / Procesamiento de Imagen Asistido por Computador / Imagen por Resonancia Magnética / Arterias Carótidas / Ultrasonografía Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Ultrasound Med Biol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido