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Factors predicting overall response and overall survival in hepatocellular carcinoma patients undergoing balloon-occluded transcatheter arterial chemoembolization: A retrospective cohort study.
Hatanaka, Takeshi; Arai, Hirotaka; Shibasaki, Mitsuhiko; Tojima, Hiroki; Takizawa, Daichi; Toyoda, Mitsuo; Takayama, Hisashi; Abe, Takehiko; Sato, Ken; Kakizaki, Satoru; Yamada, Masanobu.
Afiliación
  • Hatanaka T; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Arai H; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Shibasaki M; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Tojima H; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Takizawa D; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Toyoda M; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Takayama H; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Abe T; Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Japan.
  • Sato K; Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Kakizaki S; Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Yamada M; Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hepatol Res ; 48(2): 165-175, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28500686
AIM: This study aimed to investigate the factors predicting overall response and overall survival in hepatocellular carcinoma patients undergoing balloon-occluded transcatheter arterial chemoembolization (B-TACE). METHODS: Sixty-six patients treated with B-TACE at a Japanese tertiary referral hospital between January 2011 and August 2015 were included in this retrospective cohort study. RESULTS: The overall response was classified as complete response, partial response, stable disease, and progressive disease in 35 (53.0%), 7 (10.6%), 13 (19.7%), and 11 (16.7%) patients, respectively. The response rate was 63.6%, and the disease control rate was 83.3%. The number of tumors (hazard ratio [HR], 4.44; 95% confidence interval [CI], 1.26-15.7; P = 0.021) and α-fetoprotein level (HR, 11.40; 95% CI, 2.75-46.9; P < 0.001) were significantly associated with the tumor response in a multivariate analysis. The 1-, 2-, and 3-year survival rates were 76.8% (95% CI, 64.5-85.3%), 57.3% (95% CI, 42.3-69.7%), and 46.7% (95% CI, 30.7-61.2%), respectively. The median survival time was 902 days. Albumin (≥3.4 g/dL) (HR, 0.28; 95% CI, 0.12-0.63; P = 0.002) and overall response (complete response and partial response) (HR, 0.33; 95% CI, 0.16-0.71; P = 0.004) were factors significantly associated with overall survival in a multivariate analysis. No mortalities were observed, but biloma requiring percutaneous transhepatic biliary drainage occurred in one patient (1.5%). CONCLUSION: Balloon-occluded transcatheter arterial chemoembolization may exert a good antitumor effect and result in good overall survival in select hepatocellular carcinoma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos