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Arterial tortuosity in patients with spontaneous cervical artery dissection.
Giossi, Alessia; Mardighian, Dikran; Caria, Filomena; Poli, Loris; De Giuli, Valeria; Costa, Paolo; Morotti, Andrea; Gamba, Massimo; Gilberti, Nicola; Ritelli, Marco; Colombi, Marina; Sessa, Maria; Grassi, Mario; Padovani, Alessandro; Gasparotti, Roberto; Pezzini, Alessandro.
Afiliación
  • Giossi A; U.O Neurologia, Istituti Ospedalieri di Cremona, Cremona, Italy.
  • Mardighian D; Sezione di Neuroradiologia, Dipartimento di Specialità Medico-Chirurgiche, Scienze Radiologiche e Sanità Pubblica, Università degli Studi di Brescia, Brescia, Italy.
  • Caria F; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • Poli L; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • De Giuli V; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • Costa P; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • Morotti A; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • Gamba M; Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Italy.
  • Gilberti N; Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Italy.
  • Ritelli M; Sezione di Biologia e Genetica, Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Brescia, Italy.
  • Colombi M; Sezione di Biologia e Genetica, Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Brescia, Italy.
  • Sessa M; U.O Neurologia, Istituti Ospedalieri di Cremona, Cremona, Italy.
  • Grassi M; Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Unità di Statistica Medica e Genomica, Università di Pavia, Pavia, Italy.
  • Padovani A; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
  • Gasparotti R; Sezione di Neuroradiologia, Dipartimento di Specialità Medico-Chirurgiche, Scienze Radiologiche e Sanità Pubblica, Università degli Studi di Brescia, Brescia, Italy.
  • Pezzini A; Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy. ale_pezzini@hotmail.com.
Neuroradiology ; 59(6): 571-575, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28497262
PURPOSE: The aim of this study was to test the hypothesis that patients with spontaneous cervical artery dissection (CeAD) have increased arterial tortuosity, and the objective quantification of such a tortuosity may aid in the identification of subjects at increased risk of disease. METHODS: In the setting of a hospital-based, case-control study, we used the vertebral tortuosity index (VTI) measured on magnetic resonance angiography, a validated method for the assessment and quantification of arterial tortuosity, to compare the degree of tortuosity in a series of consecutive patients with spontaneous CeAD and of age- and sex-matched patients with ischemic stroke unrelated to CeAD (non-CeAD IS) and stroke-free subjects. RESULTS: The study group was composed of 102 patients with CeAD (mean age, 44.5 ± 7.8 years; 66.7% men), 102 with non-CEAD IS, and 102 stroke-free subjects. The VTI was higher in the group of patients with CeAD (median, 7.3; 25th-75th percentile, 10.2) compared with that of non-CeAD IS (median, 3.4; 25th-75th percentile, 4.4) and of stroke-free subjects (median, 4.0; 25th-75th percentile, 2.9; p ≤ 0.001), and was independently associated to the risk of CeAD (OR, 1.18; 95% CI, 1.09-1.29) in multivariable regression analysis. The degree of tortuosity also tended to be higher in CeAD patients who experienced short-term recurrence (5.8%; median, 20.2; 25th-75th percentile, 31.2) than in those without recurrent events (median, 7.2; 25th-75th percentile, 9.4; p = 0.074). CONCLUSION: CeAD patients exhibit increased arterial tortuosity. This might have potential implications for better understanding of the pathophysiology of the disease as well as clinical utility in evaluation, prognostication, and decision-making of affected individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias / Enfermedades Cutáneas Genéticas / Angiografía por Resonancia Magnética / Disección de la Arteria Vertebral / Malformaciones Vasculares / Inestabilidad de la Articulación Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroradiology Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias / Enfermedades Cutáneas Genéticas / Angiografía por Resonancia Magnética / Disección de la Arteria Vertebral / Malformaciones Vasculares / Inestabilidad de la Articulación Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroradiology Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania