Synthesis, crystal structure determination, biological screening and docking studies of N<sup>1</sup>-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases.

Sultana, Nargis; Sarfraz, Muhammad; Tanoli, Saba Tahir; Akram, Muhammad Safwan; Sadiq, Abdul; Rashid, Umer; Tariq, Muhammad Ilyas

Synthesis, crystal structure determination, biological screening and docking studies of N¹-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases.

Sultana, Nargis; Sarfraz, Muhammad; Tanoli, Saba Tahir; Akram, Muhammad Safwan; Sadiq, Abdul; Rashid, Umer; Tariq, Muhammad Ilyas.

Afiliación

Sultana N; Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
Sarfraz M; Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
Tanoli ST; Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
Akram MS; School of Science & Engineering, Teesside University, Middlesbrough, Tees Valley TS1 3BA, UK.
Sadiq A; Department of Pharmacy, University of Malakand, Chakdara 18000 Dir (L), Pakistan.
Rashid U; Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: umerrashid@ciit.net.pk.
Tariq MI; Department of Chemistry, University of Sargodha, Sargodha, Pakistan. Electronic address: tariqmi2000@yahoo.com.

Bioorg Chem ; 72: 256-267, 2017 06.

Article en En | MEDLINE | ID: mdl-28495556

Asunto(s)

Inhibidores de la Colinesterasa/farmacología; Colinesterasas/metabolismo; Quinazolinonas/farmacología; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/química; Cristalografía por Rayos X; Relación Dosis-Respuesta a Droga; Humanos; Modelos Moleculares; Estructura Molecular; Quinazolinonas/síntesis química; Quinazolinonas/química; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; Benzylation; Cholinesterases; Computational studies; N-alkylated-2,3-dihydroquinazolin-4(1H)-one

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Colinesterasa / Colinesterasas / Quinazolinonas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2017 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos

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